| ORIGINAL ARTICLES |
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Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng |
| Wen-Jie Sun1,2, Hong-Tao Zhu1, Tian-Yuan Zhang3, Meng-Yue Zhang3, Dong Wang1, Chong-Ren Yang1, Yi-Xuan Zhang3, Ying-Jun Zhang1,4 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China;
4 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China |
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Abstract Panax notoginseng (Araliaceae) is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of China. Two new alkaloids, rigidiusculamide E (1) and[-(α-oxyisohexanoyl-N-methyl-leucyl)2-] (2), together with two known ones, (-)-oxysporidinone (3) and (-)-4,6'-anhydrooxysporidinone (4) were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082, an endophytic fungus obtained from the healthy root of P. notoginseng. Their structures were determined on the basis of extensive spectroscopic analyses. Compounds 1-4 were tested for their inhibitory effects against NO production on Murine macrophage cell line, and the new compound 2 showed significant inhibitory activity on NO production with the IC50 value of 18.10 ±0.16 μM.
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| Keywords
Fusarium tricinctum SYPF 7082
Endophytic fungus
Alkaloids
Panax notoginseng
Inhibition on NO production
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| Fund:This work was supported by the Major Science and Technique Programs in Yunnan Province (2016ZF001-001, 2017IB038), the Science and Technology Planning Project of Yunnan Province (2013FC008, 2015IC017) and the National Science and Technology Major Project of China (2018ZX09735001-002-002). |
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Corresponding Authors:
Yi-Xuan Zhang, Ying-Jun Zhang
E-mail: zhangyxzsh@163.com;zhangyj@mail.kib.ac.cn
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Issue Date: 19 September 2018
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