Secondary Metabolites from the Endophytic Fungus <i>Xylaria</i> sp. Hg1009

doi:10.1007/s13659-018-0158-x

Natural Products and Bioprospecting

2018, Vol. 8

Issue (2) : 121-129 DOI: 10.1007/s13659-018-0158-x

ORIGINAL ARTICLES

Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009

Rong Chen^1,2, Jian-Wei Tang^2,3, Xing-Ren Li², Miao Liu², Wen-Ping Ding^1,2, Yuan-Fei Zhou^2,3, Wei-Guang Wang², Xue Du², Han-Dong Sun², Pema-Tenzin Puno²

1 School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

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Abstract A detailed chemical investigation of the secondary metabolites produced by the endophytic fungus Xylaria sp. isolated from the stems of Isodon sculponeatus afforded six new compounds, xylariahgins A-F (1-6), two new natural products (7 and 8), along with two known compounds (9 and 10) (Fig. 1). The structures of all compounds were unambiguously established by analyzing their spectroscopic data or referring to pertinent literature. Compounds 1-8 were tested for their cytotoxic activity against five human tumor cell lines.

Keywords Endophytic fungus Xylaria sp. Secondary metabolites Cytotoxicity

Fund:This project was supported financially by the National Natural Science Foundation of China (81673329 and 21322204).

Corresponding Authors: Pema-Tenzin Puno E-mail: punopematenzin@mail.kib.ac.cn

Issue Date: 26 April 2018

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	Rong Chen
	Jian-Wei Tang
	Xing-Ren Li
	Miao Liu
	Wen-Ping Ding
	Yuan-Fei Zhou
	Wei-Guang Wang
	Xue Du
	Han-Dong Sun
	Pema-Tenzin Puno

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Rong Chen,Jian-Wei Tang,Xing-Ren Li, et al. Secondary Metabolites from the Endophytic Fungus Xylaria sp. Hg1009[J]. Natural Products and Bioprospecting, 2018, 8(2): 121-129.

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http://npb.kib.ac.cn/EN/10.1007/s13659-018-0158-x OR http://npb.kib.ac.cn/EN/Y2018/V8/I2/121

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