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Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan |
| Xin Wei1,2,3, Afsar Khan1,4, Da Song5, Zhi Dai2,6, Ya-Ping Liu1,3, Hao-Fei Yu1,2,3, Bei Wang1,2,3, Pei-Feng Zhu1,2,3, Cai-Feng Ding1,2,3, Xu-Dong Zhao6, Yi-Fen Wang1,3, Xiao-Dong Luo1,3 |
1. State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
4. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;
5. Yunnan College of Business Management, Kunming 650106, People's Republic of China;
6. Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People's Republic of China |
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Abstract Three new pyridine type alkaloids, (-)-vinmajpyridines A-C (1-3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3# and GITC-18#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.
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| Keywords
Vinca major
Apocynaceae
Pyridine alkaloids
Cytotoxicity
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| Fund:The authors are grateful to the National Natural Science Foundation of China (81225024) for financial support. |
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Issue Date: 07 February 2018
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