Natural Products and Bioprospecting    2017, Vol. 7 Issue (2) : 181-199     DOI: 10.1007/s13659-017-0123-0
Review |
The Genus Carissa: An Ethnopharmacological, Phytochemical and Pharmacological Review
Joseph Sakah Kaunda1,2, Ying-Jun Zhang1,3
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China;
3. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China
Download: PDF(990 KB)   HTML ()  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  Carissa L. is a genus of the family Apocynaceae, with about 36 species as evergreen shrubs or small trees native to tropical and subtropical regions of Africa, Asia and Oceania. Most of Carissa plants have been employed and utilized in traditional medicine for various ailments, such as headache, chest complains, rheumatism, oedema, gonorrhoea, syphilis, rabies. So far, only nine Carissa species have been phytochemically studied, which led to the identification of 123 compounds including terpenes, flavonoids, lignans, sterols, simple phenolic compounds, fatty acids and esters, and so on. Pharmacological studies on Carissa species have also indicated various bioactive potentials. This review covers the peerreviewed articles between 1954 and 2016, retrieved from Pubmed, ScienceDirect, SciFinder, Wikipedia and Baidu, using "Carissa" as search term ("all fields") and with no specific time frame set for search. Fifteen important medicinal or ornamental Carissa species were selected and summarized on their botanical characteristics, geographical distribution, traditional uses, phytochemistry, and pharmacological activities.
Keywords Carissa      Apocynaceae      Ethnomedicine      Phytochemistry      Triterpenes      Nortrachelogenin      Pharmacology     
Issue Date: 06 February 2018
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Joseph Sakah Kaunda
Ying-Jun Zhang
Trendmd:   
Cite this article:   
Joseph Sakah Kaunda,Ying-Jun Zhang. The Genus Carissa: An Ethnopharmacological, Phytochemical and Pharmacological Review[J]. Natural Products and Bioprospecting, 2017, 7(2): 181-199.
URL:  
http://npb.kib.ac.cn/EN/10.1007/s13659-017-0123-0     OR     http://npb.kib.ac.cn/EN/Y2017/V7/I2/181
1. E.A. Lindsay, J.F. Jamie, J.B. Bremner, Phytochemistry. 55, 403-406 (2000)
2. P.B. Stoffel, South Africa National Biodiversity Institute (2004), http://www.plantzafrica.com/plantcd/carisbispin.htm. Accessed 23 Aug 2016
3. Editorial Committee of Flora of China, Chinese Academy of Sciences, Flora of China, vol. 63 (Science Press, Beijing, 1989-2013), p. 9
4. M. Moudachirou, M.A. Ayédoun, J.D. Gbénou, Oil Res. 10, 195-196 (1998)
5. H. Al-Youssef, W.H.B. Hassan, Biosci. Biotechnol. Res. Asia 7, 635-646 (2010)
6. R. Saeed, D. Ahmed, Pharmacogn. Res. 7, 295-301 (2015)
7. A.Y. Zaki, S.F. El-Tohamy, S.A. El-Fattah, Egypt. J. Pharm. Sci. 22, 127-141 (1983)
8. H. Achenbach, R. Waibel, I. Addae-Mensah, Phytochemistry 24, 2325-2328 (1985)
9. H. Achenbach, R. Waibel, I. Addae-Mensah, Phytochemistry 22, 749-753 (1983)
10. H.M. Al-Youssef, H.B.H. Wafaa, Int. J. Curr. Res. Chem. Pharm. Sci. 1(9), 12-24 (2014)
11. D.V. Joshi, S.F. Boyce, J. Org. Chem. 22, 95-97 (1957)
12. J. Reisch, R.A. Hussain, 121, 941-944 (1990)
13. D. Ahmed, K. Fatima, Nat. Prod. Res. 30, 2012-2016 (2016)
14. P.R. Itankar, S.J. Lokhande, J. Ethnopharmacol. 135, 430-433 (2011)
15. S.C. Pakrashi, S. Datta, Phytochemistry 7, 495-496 (1967)
16. M. Arif, S. Fareed, J. Med. Aromat. Plant Sci. 33, 53-58 (2011)
17. G.M. Doshi, V.V. Nalawade, Pharmacogn. Res. 7, 282-293 (2015)
18. R. Moodley, H. Chenia, J. Med. Plants Res. 5, 4851-4858 (2011)
19. V. Mathuram, A. Brahmadhayalaselvam, J. Indian Chem. Soc. 75, 262-264 (1998)
20. M.M. Motawi, Y.E. Hammouda, Egypt. Pharm. Bull. 44, 49-54 (1964)
21. R.J. Rao, U.S. Kumar, Nat. Prod. Res. 19, 763-769 (2005)
22. B. Hegde, P. Shalin, Asian J. Chem. 21, 5399-5402 (2009)
23. A.Y. Zaki, S.F. El-Tohamy, J. Pharm. Sci. 22, 113-126 (1983)
24. S. Begum, S.A. Syed, Phytochem. Lett. 6, 91-95 (1983)
25. Z. Naim, M.A. Khan, S.S. Nizami, Pak. J. Sci. Ind. Res. 31, 753-755 (1988)
26. S. Parveen, M. Saleem, N. Riaz, J. Asian Nat. Prod. Res. 18, 222-231 (2016)
27. Z. Naim, M.A. Khan, S.S. Nizami, Pak. J. Sci. Ind. Res. 28, 378-381 (1985)
28. R.C. Rastogi, D.K. Kulshreshtha, R.P. Rastogi, Indian J. Chem. 7, 1102-1104 (1969)
29. K. Mohr, O. Schindler, T. Reichstein, Helv. Chim. Acta 37, 462-471 (1954)
30. R.C. Rastogi, M.M. Vohra, R.P. Rastogi, M.L. Dhar, Indian J. Chem. 4, 132-138 (1966)
31. K. Hegde, A.B. Joshi, Res. J. Pharm. Technol. 3, 217-220 (2010)
32. B. Patil, P. Rajaram, R. Sandeep, Crit. Rev. Food Sci. Nutr. 52, 312-320 (2012)
33. G.M. Doshi, H.D. Une, Pharmacogn. Res. 8, 37-42 (2016)
34. R. Wangteeraprasert, V. Lipipun, M. Gunaratnam et al., Phytother. Res. 26, 1496-1499 (2012)
35. R. Pal, D.K. Kulshreshtha, R.P. Rastogi, Phytochemistry 14, 2302-2303 (1975)
36. D.S. Hettiarachchi, C. Locher, R.B. Longmore, Nat. Prod. Res. 25, 1388-1395 (2011)
37. K. Hegde, D. Satyanarayana, A.B. Joshi, Rajiv Gandhi Univ. Health Sci. J. Pharm. Sci. 2, 55-59 (2012)
38. N. Balakrishnan, A. Balasubaramaniam, B. Sangameswaran, J. Nat. Pharm. 2, 92-98 (2011)
39. M.K. Raina, J.K. Bhatnagar, C.K. Atal, Indian J. Pharm. 33, 76-77 (1971)
40. R.M. Shrivastava, M.M. Bokadia, J. Sci. Res. 1, 57-60 (1979)
41. P.G. Kirira, G.M. Rukunga, A.W. Wanyonyi, J. Ethnopharmacol. 106, 403-407 (2006)
42. T. Nedi, N. Mekonnen, K. Urga, J. Ethnopharmacol. 95, 57-61 (2004)
43. J. Ya'u, A.H. Yaro, M.S. Abubakar, J. Ethnopharmacol. 120, 255-258 (2008)
44. M. Fartyal, P. Kumar, Elixir Int. J. Sept. 26997-27001 (2014)
45. S. Verma, H.S. Chaudhary, J. Pharm. Res. 4, 3769-3771 (2011)
46. D. Dua, N.S. Srivastav, Int. J. Integr. Sci. Innov. Technol. 2, 15-19 (2013)
47. I. Sehar, H.C. Pal, S. Shukla, J. Pharm. Pharmacol. 63, 1078-1090 (2011)
48. V. Khushbu, S. Divya, K. Gaurav, J. Taibah Univ. Sci. 9, 34-40 (2015)
49. S. Nisa, Y. Bibi, M. Zia, Pak. J. Pharm. Sci. 26, 1009-1012 (2013)
50. A.M. Allahverdiyev, M. Bagirova, S. Yaman, in Development of New Antiherpetic Drugs Based on Plant Compounds, eds. by M. Rai, K. Kon. Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components (Elsevier, Amsterdam, 2013), pp. 245-259
51. F.M. Tolo, G.M. Rukunga, F.W. Muli, J. Ethnopharmacol. 104, 92-99 (2006)
52. V.P. Bagla, L.J. McGaw, J.N. Eloff, Vet. Microbiol. 155, 198-206 (2012)
53. H.M. Mohtasheemul, A. Salman, A. Ziauddin, A. Iqbal, J. Pharm. Sci. Innov. 1, 47-49 (2012)
54. S. Sumbul, S.I. Ahmed, J. Basic Appl. Sci. 8, 124-134 (2012)
55. V.H. Bhaskar, N. Balakrishnan, J. Fac. Pharm. Tehran Univ. Med. Sci. 17, 168-174 (2009)
56. S. Galipalli, N.K. Patel, K. Prasanna, K.K. Bhutani, Nat. Prod. Res. 29, 1670-1672 (2015)
57. K. Hegde, A.B. Joshi, Pharm. Lett. 2, 255-260 (2010)
58. F.P. Ruphin, R. Baholy, R. Amelie, Pharmacology 6, 88-96 (2015)
59. S. Sahreen, M.R. Khan, R.A. Khan, H.M. Alkreathy, BMC Res. Notes. 7, 224 (2014)
60. K. Saxena, R. Irchhaiya, K.K. Chagti, World J. Pharm. Pharm. Sci. 5, 1683-1690 (2016)
61. V.H. Bhaskar, N. Balakrishnan, Pharm. Lett. 1, 130-142 (2009)
62. K. Hegde, A.B. Joshi, Indian J. Exp. Biol. 47, 660-667 (2009)
63. F.K. Elfiky, M.A. Aboukaram, E.A. Afify, J. Ethnopharmacol. 50, 43-47 (1996)
64. S.N. Joglekar, B.B. Gaitonde, Jpn. J. Pharmacol. 20, 367-372 (1970)
65. O.Q. Jan, A. Ashraf, R.K. Sharma, J. Parasit. Dis. Off. Organ Indian Soc. Parasitol. 39, 41-48 (2015)
66. Carissa, https://en.wikipedia.org/wiki/Carissa. Accessed 23 Aug 2016
67. M.H. Mehmood, N. Anila, S. Begum, J. Ethnopharmacol. 153, 359-367 (2014)
68. S.C. Pakrashi, S. Datta, P.P. Ghosh-Dastidar, Phytochemistry 7, 495-496 (1968)
69. B. Janardhan, V.M. Shrikanth, K.K. Mirajkar, S.S. More et al., J. Herbs Spices Med. Plants 21, 283-293 (2015)
70. J.F. Morton, Fruits of Warm Climates (1987), pp. 422-424, https://hort.purdue.edu/newcrop/morton/karnda.html. Accessed 23 Aug 2016
71. Carissa, http://www.growables.org/information/TropicalFruit/carissa.htm. Accessed 23 Aug 2016
72. A Database of Indigenous South African Flora, Carissa haematocarpa, http://kumbulanursery.co.za/plants/carissa-haematocarpa. Accessed 23 Aug 2016
73. I. Sania, A. Dildar, Chem. Sel. 1, 3005-3011 (2016), http://onlinelibrary.wiley.com/wol1/doi/10.1002/slct.201600462/full. Accessed 23 Aug 2016
74. R. Brown, Prodromus Florae Novae Hollandiae (1810), http://keys.trin.org.au/key-server/data/0e0f0504-0103-430d-8004-060d07080d04/media/Html/taxon/Carissa_ovata.htm. Accessed 22 Sep 2016
75. Carissa ovata (Apocynanceae) Currant Bush, Kunkerberry, http://www.saveourwaterwaysnow.com.au/01_cms/details_pop. asp?ID=120. Accessed 22 Sep 2016
76. Carissa spinarum Linn., https://hort.purdue.edu/newcrop/parmar/04.html. Accessed 22 Sep 2016
77. M.L. Chatterjee, A.R. Roy, Bull. Calcutta Sch. Trop. Med. 13, 14-16 (1965)
78. R. Sanwal, A.K. Chaudhary, J. Ethnopharmacol. 135, 792-796 (2011)
79. S.N. Wambugu, P.M. Mathiu, D.W. Gakuya, J. Ethnopharmacol. 137, 945-955 (2011)
80. Carissa, http://frps.eflora.cn/frps/Carissa. Accessed 23 Aug 2016
81. S. Sahreen, M.R. Khan, R.A. Khan, Food Chem. 122, 1205-1211 (2010)
82. K.M. Kim, D.R. Heo, Y.-A. Kim, Environ. Toxicol. Pharmacol. 48, 85-93 (2016)
[1] Xin Wei, Afsar Khan, Da Song, Zhi Dai, Ya-Ping Liu, Hao-Fei Yu, Bei Wang, Pei-Feng Zhu, Cai-Feng Ding, Xu-Dong Zhao, Yi-Fen Wang, Xiao-Dong Luo. Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan[J]. Natural Products and Bioprospecting, 2017, 7(4): 323-327.
[2] Satheesh Kumar Palanisamy, N. M. Rajendran, Angela Marino. Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development[J]. Natural Products and Bioprospecting, 2017, 7(1): 1-111.
[3] Hassan KHALID, Wail Elsadig ABDALLA, Haider ABDELGADIR, Till OPATZ, Thomas EFFERTH. Gems from traditional north-African medicine: medicinal and aromatic plants from Sudan[J]. Natural Products and Bioprospecting, 2012, 2(3): 92-103.
[4] Mei-Fen BAO, Chun-Xia ZENG, Yan QU, Ling-Mei KONG, Ya-Ping LIU, Xiang-Hai CAI, Xiao-Dong LUO. Monoterpenoid indole alkaloids from Alstonia rostrata[J]. Natural Products and Bioprospecting, 2012, 2(3): 121-125.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed