α-Pyrone Derivatives from a <i>Streptomyces</i> Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells

doi:10.1007/s13659-017-0136-8

Natural Products and Bioprospecting

2017, Vol. 7

Issue (4) : 329-334 DOI: 10.1007/s13659-017-0136-8

Original article

α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells

Rui-Min Yang^1,2, Xiu-Lei Zhang¹, Li Wang¹, Jian-Ping Huang¹, Jing Yang¹, Yi-Jun Yan¹, Jian-Ying Luo¹, Xiang-Ting Wang¹, Sheng-Xiong Huang¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China

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Abstract Tamoxifen resistance (TamR) is the underlying cause of treatment failure in many breast cancer patients receiving tamoxifen. In order to look for noncytotoxic natural products with the ability to reverse TamR, an extract from strain Streptomyces sp. KIB-H0495 was detected to be active. Subsequent large scale fermentation and isolation led to the isolation of four α-pyrone derivatives including two new compounds, violapyrones J (2) and K (3), and two known analogues, violapyrones B (1) and I (4). Further bioactivity assays indicated that only 1 and 3 exerted potent resensitization effects on MCF-7/TamR cells at a concentration of 1 μM. Owing to the simple structures of 1 and 3, these two compounds might have potential for further investigation as novel tamoxifen resensitization agent in breast cancer chemotherapy.

Keywords Breast cancer Tamoxifen resistance Resensitization α-Pyrone derivatives Streptomyces

Fund:This research was financially supported by the National Natural Science Foundation of China to S-X.H (No. 81522044) and to X.W (No. 31471226), High-end Science and Technology Talents Program of Yunnan Province to S-X.H (No. 2013HA022), and a Grant from the Thousand Youth Talents Program of China.

Issue Date: 07 February 2018

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	Rui-Min Yang
	Xiu-Lei Zhang
	Li Wang
	Jian-Ping Huang
	Jing Yang
	Yi-Jun Yan
	Jian-Ying Luo
	Xiang-Ting Wang
	Sheng-Xiong Huang

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Rui-Min Yang,Xiu-Lei Zhang,Li Wang, et al. α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells[J]. Natural Products and Bioprospecting, 2017, 7(4): 329-334.

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http://npb.kib.ac.cn/EN/10.1007/s13659-017-0136-8 OR http://npb.kib.ac.cn/EN/Y2017/V7/I4/329

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[1]	Dmitri O. Levitsky, Valery M. Dembitsky. Anti-breast Cancer Agents Derived from Plants[J]. Natural Products and Bioprospecting, 2015, 5(1): 1-16.

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