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Five New Alkaloids from Cephalotaxus lanceolata and C. fortunei var. alpina |
| Ling Ni1,2, Xiu-Hong Zhong1,2, Jie Cai3, Mei-Fen Bao1,2, Bing-Jie Zhang1, Jing Wu1,2, Xiang-Hai Cai1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China;
3. Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China |
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Abstract Five new alkaloids (1-5) were isolated from the leaves and twigs of Cephalotaxus lanceolata and C. fortunei var. alpina along with 24 known alkaloids. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, FTIR, UV and MS. These new alkaloids showed no cytotoxicity to HeLa, SGC-7901 gastric cancer, and A-549 lung cancer cell lines.
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| Keywords
Cephalotaxus
Alkaloids
Cytotoxicity
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| Fund:This project was financially supported by the Young Academic and Technical Leader Raising Foundation of Yunnan Province (No.2010CI049) |
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Issue Date: 08 February 2018
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1. W.W. Paudler, G.I. Kerley, J. McKay, J. Org. Chem. 28, 2194 (1963)
2. R.G. Powell, R.V. Madrigal, C.R. Smith Jr, K.L. Mikolajczak, J. Org. Chem. 39, 676 (1974)
3. I. Takano, I. Yasuda, M. Nishijima, Y. Hitotsuyanagi, K. Takeya, H. Itokawa, Bioorg. Med. Chem. Lett. 6, 1689 (1996)
4. H. Morita, M. Arisaka, N. Yoshida, Tetrahedron 56, 2929 (2000)
5. H. Morita, M. Yoshinaga, J.I. Kobayashi, Tetrahedron 58, 5489 (2002)
6. L.W. Wang, H.J. Su, S.Z. Yang, S.J. Won, C.N. Lin, J. Nat. Prod. 67, 1182 (2004)
7. J.G. Buta, J.L. Flippen, W.R. Lusby, J. Org. Chem. 43, 1002 (1978)
8. J. Du, M.H. Chiu, R.L. Nie, J. Nat. Prod. 62, 1664 (1999)
9. Y.R. He, Y.H. Shen, L. Shan, X. Yang, B. Wen, J. Ye, X. Yuan, H.L. Li, X.K. Xu, W.D. Zhang, RSC Adv. 5, 4126 (2015)
10. K.D. Yoon, D.G. Jeong, Y.H. Hwang, J.M. Ryu, J. Kim, J. Nat. Prod. 70, 2029 (2007)
11. K.D. Yoon, Y.W. Chin, J.W. Kim, Bull. Korean Chem. Soc. 31, 495 (2010)
12. H. Abdelkafi, B. Nay, Nat. Prod. Rep. 29, 845 (2012)
13. R. Powell, Phytochemistry 11, 1467 (1972)
14. R. Powell, D. Weisleder, C. Smith, J. Pharm. Sci. 61, 1227 (1972)
15. R. Powell, K. Mikolajczak, Phytochemistry 12, 2987 (1973)
16. S. Asada, Yakugaku Zasshi 93, 916 (1973)
17. R. Powell, D. Weisleder, C. Smith, I. Wolff, Tetrahedron Lett. 10, 4081 (1969)
18. N. Langlois, J. Razafimbelo, J. Nat. Prod. 51, 499 (1988)
19. J.S. Fitzgerald, S. Johns, J. Lamberton, A. Sioumis, Aust. J. Chem. 22, 2187 (1969)
20. S. Johns, J. Lamberton, A. Sioumis, Aust. J. Chem. 22, 2219 (1969)
21. L. Lacombe, N. Langlois, B. Das, P. Potier, Bull. Soc. Chim. Fr. 10, 3535 (1970)
22. M.H. Qiu, B.P. Lu, X. Ma, R.L. Nie, Acta Botanica Yunnanica 19, 99 (1997)
23. F. Chang, C. Wang, W. Pan, Y. Li, L. Mai, C. Sun, K. Ma, J. Integr. Plant Biol. 20, 129 (1978)
24. S. Li, Y. Cui, Y. Li, X. Pan, Y. Wang, W. Hung, Acta Chim. Sinica 45, 687 (1987)
25. R. Powell, D. Weisleder, C. Smith, W. Rohwedder, Tetrahedron Lett. 11, 815 (1970)
26. S.B. Li, Y.X. Cui, X.Y. Nie, X.X. Pan, Y.L. Li, Sci. Bull. 33, 1436 (1988)
27. W.K. Huang, Y.L. Li, X.X. Pan, Sci. China Ser. A 23, 835 (1980)
28. K. Mikolajczak, R. Powell, C. Smith, Tetrahedron 28, 1995 (1972) |
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