Natural Products and Bioprospecting    2016, Vol. 6 Issue (3) : 155-160     DOI: 10.1007/s13659-016-0094-6
Original article |
Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23
Ce Kuang1,2, Shu-Xi Jing1, Yan Liu1, Shi-Hong Luo1, Sheng-Hong Li1
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences(CAS), Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China
Download: PDF(715 KB)   HTML ()  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  Three new drimane sesquiterpenoids (1-3) together with the known 2α-hydroxyisodrimeninol (4), and a new isochromone derivative (5), were obtained from the solid cultures of fungal strain Pestalotiopsis sp. M-23, an endophytic fungus isolated from the leaves of Leucosceptrum canum (Labiatae). Their structures were determined by comprehensive 1D and 2D NMR, and MS analyses. The metabolites were evaluated for their antibacterial activities, and compound 3 showed weak inhibitory activity against Bacillus subtilis.
Keywords Endophytic fungi      Pestalotiopsis sp. M-23      Leucosceptrum canum      Drimane sesquiterpenoids      Antibacterial activity     
Fund:This work was supported financially by the National Natural Science Foundation of China (Nos.31525005,U1202263,31570362);the Youth Innovation Promotion association of Chinese Academy of Sciences (awarded to Shi-Hong Luo),the "Western Light" Program of Chinese Academy of Sciences (awarded to Shi-Hong Luo);the "Hundred Talents Program" of the Chinese Academy of Sciences (awarded to Sheng-Hong Li)
Issue Date: 08 February 2018
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Ce Kuang
Shu-Xi Jing
Yan Liu
Shi-Hong Luo
Sheng-Hong Li
Trendmd:   
Cite this article:   
Ce Kuang,Shu-Xi Jing,Yan Liu, et al. Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23[J]. Natural Products and Bioprospecting, 2016, 6(3): 155-160.
URL:  
http://npb.kib.ac.cn/EN/10.1007/s13659-016-0094-6     OR     http://npb.kib.ac.cn/EN/Y2016/V6/I3/155
1. A.E. Arnold, Z. Maynard, G.S. Gilbert, P.D. Coley, T.A. Kursar, Ecol. Lett. 3, 267-274 (2000)
2. J.J. De Souza, I.J. Curcino, E. Rodrigues Filho, R. Braz Filho, Molecules 16, 10604-10618 (2011)
3. A. Stierle, G. Strobel, D. Stierle, Science 260, 214-216 (1993)
4. S. Kusari, S. Zühlke, J. Kosuth, E. Cellarova, M. Spiteller, J. Nat. Prod. 72, 1825-1835 (2009)
5. S. Kusari, M. Lamshoeft, S. Zuehlke, M. Spiteller, J. Nat. Prod. 71, 159-162 (2008)
6. X.L. Yang, J.Z. Zhang, D.Q. Luo, Nat. Prod. Rep. 29, 622-641 (2012)
7. S.C. Liu, L.D. Guo, Y.S. Che, L. Liu, Fitoterapia 85, 114-118 (2013)
8. H.E. Ortega, Y.Y. Shen, K. Tendyke, N. Rios, L. Cubilla-Rios, Tetrahedron Lett. 55, 2642-2645 (2014)
9. S.C. Liu, X.Y. Liu, L.D. Guo, Y.S. Che, L. Liu, Chem. Biodivers. 10, 2007-2013 (2013)
10. S.H. Luo, Q. Luo, X.M. Niu, M.J. Xie, X. Zhao, B. Schneider, J. Gershenzon, S.H. Li, Angew. Chem. Int. Ed. 49, 4471-4475 (2010)
11. S.H. Luo, Y. Liu, J. Hua, X.M. Niu, S.X. Jing, X. Zhao, B. Schneider, J. Gershenzon, S.H. Li, Org. Lett. 14, 4146-4149 (2012)
12. S.H. Luo, L.H. Weng, M.J. Xie, X.N. Li, J. Hua, X. Zhao, S.H. Li, Org. Lett. 13, 1864-1867 (2011)
13. S.H. Luo, J. Hua, C.H. Li, Y. Liu, X.N. Li, X. Zhao, S.H. Li, Tetrahedron Lett. 54, 235-237 (2013)
14. S.H. Luo, C.L. Hugelshofer, J. Hua, S.X. Jing, C.H. Li, Y. Liu, X.N. Li, X. Zhao, T. Magauer, S.H. Li, Org. Lett. 16, 6416-6419 (2014)
15. S. Phongpaichit, N. Rungjindamai, V. Rukachaisirikul, J. Sakayaroj, FEMS Immunol. Med. Microbiol. 48, 367-372 (2006)
16. R. Ren, C.J. Chen, S.S. Hu, H.M. Ge, W.Y. Zhu, R.X. Tan, R.H. Jiao, Chem. Biodivers. 12, 371-379 (2015)
17. Y. Sakio, Y.J. Hirano, M. Hayashi, K. Komiyama, M. Ishibashi, J. Nat. Prod. 64, 726-731 (2001)
18. M. Pulici, F. Sugawara, H. Koshino, J. Uzawa, S. Yoshida, E. Lobkovsky, J. Clardy, J. Nat. Prod. 59, 47-48 (1996)
19. X.Y. Yang, T. Feng, J.H. Ding, Z.H. Li, Y. Li, Q.Y. Fan, J.K. Liu, Nat. Prod. Bioprospect. 3, 154-157 (2013)
20. H. Koshino, T. Yoshihara, M. Okuno, S. Sakamura, A. Tajimi, T. Shimanuki, Biosci. Biotechnol. Biochem. 56, 1096-1099 (1992)
21. S. Felix, L.P. Sandjo, T. Opatz, G. Erkel, Bioorgan. Med. Chem. 22, 2912-2918 (2014)
22. J.W. Zhang, G.L. Wen, L. Zhang, D.M. Duan, Z.H. Ren, Bangl. J. Pharmacol. 10, 844-853 (2015)
23. H. Keskes, M. Litaudon, A. Cherif, S. Belhadj, B. Hamdi, A. El Feki, V. Dumontet, A. Ben Salah, M. Damak, N. Allouche, J. Asian Nat. Prod. Res. 16, 1132-1138 (2014)
24. I. Wiegand, K. Hilpert, R.E.W. Hancock, Nat. Protoc. 3, 163-175 (2008)
25. L.J. Reed, H. Muench, Am. J. Epidemiol. 27, 493-497 (1938)
[1] Michel Feussi Tala, Jianchun Qin, Joseph T. Ndongo, Hartmut Laatsch. New Azulene-Type Sesquiterpenoids from the Fruiting Bodies of Lactarius deliciosus[J]. Natural Products and Bioprospecting, 2017, 7(3): 269-273.
[2] Xiao-Yan YANG, Tao FENG, Jian-Hai DING, Zheng-Hui LI, Yan LI, Qiong-Ying FAN, Ji-Kai LIU. Two new drimane sesquiterpenoids from cultures of the basidiomycete Trichaptum biforme[J]. Natural Products and Bioprospecting, 2013, 3(4): 154-157.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed