Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus <i>Pestalotiopsis</i> sp. M-23

doi:10.1007/s13659-016-0094-6

Natural Products and Bioprospecting

2016, Vol. 6

Issue (3) : 155-160 DOI: 10.1007/s13659-016-0094-6

Original article

Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23

Ce Kuang^1,2, Shu-Xi Jing¹, Yan Liu¹, Shi-Hong Luo¹, Sheng-Hong Li¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences(CAS), Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

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Abstract Three new drimane sesquiterpenoids (1-3) together with the known 2α-hydroxyisodrimeninol (4), and a new isochromone derivative (5), were obtained from the solid cultures of fungal strain Pestalotiopsis sp. M-23, an endophytic fungus isolated from the leaves of Leucosceptrum canum (Labiatae). Their structures were determined by comprehensive 1D and 2D NMR, and MS analyses. The metabolites were evaluated for their antibacterial activities, and compound 3 showed weak inhibitory activity against Bacillus subtilis.

Keywords Endophytic fungi Pestalotiopsis sp. M-23 Leucosceptrum canum Drimane sesquiterpenoids Antibacterial activity

Fund:This work was supported financially by the National Natural Science Foundation of China (Nos.31525005,U1202263,31570362);the Youth Innovation Promotion association of Chinese Academy of Sciences (awarded to Shi-Hong Luo),the "Western Light" Program of Chinese Academy of Sciences (awarded to Shi-Hong Luo);the "Hundred Talents Program" of the Chinese Academy of Sciences (awarded to Sheng-Hong Li)

Issue Date: 08 February 2018

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Ce Kuang,Shu-Xi Jing,Yan Liu, et al. Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23[J]. Natural Products and Bioprospecting, 2016, 6(3): 155-160.

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http://npb.kib.ac.cn/EN/10.1007/s13659-016-0094-6 OR http://npb.kib.ac.cn/EN/Y2016/V6/I3/155

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