Pharmacological and Predicted Activities of Natural Azo Compounds

doi:10.1007/s13659-016-0117-3

Natural Products and Bioprospecting

2017, Vol. 7

Issue (1) : 151-169 DOI: 10.1007/s13659-016-0117-3

Original Article

Pharmacological and Predicted Activities of Natural Azo Compounds

Valery M. Dembitsky¹, Tatyana A. Gloriozova², Vladimir V. Poroikov²

1. National Scientific Center of Marine Biology, 17 Palchevsky Str., Vladivostok, Russia 690041;
2. Institute of Biomedical Chemistry, Moscow, Russia 119121

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Abstract This paper describes research on natural azo compounds isolated from fungi, plant, bacteria, and invertebrates. More than 120 biologically active diazene containing alkaloids demonstrate confirmed pharmacological activity, including antitumor, antimicrobial, and antibacterial effects. The structures, origin, and biological activities of azo compounds are reviewed. Utilizing the computer program PASS, some structure-activity relationship new activities are also predicted, pointing toward possible new applications of these compounds. This article emphasizes the role of natural azo compounds as an important source of drug prototypes and leads for drug discovery.

Keywords Azo metabolites Alkaloids Fungi Plant Bacteria Sponges SAR

Fund:The work was partially supported (TAG and VVP) in the framework of the Russian State Academies of Sciences Fundamental Research Program for 2013-2020.

About author: 10.1007/s13659-016-0117-3

Issue Date: 06 February 2018

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Valery M. Dembitsky,Tatyana A. Gloriozova,Vladimir V. Poroikov. Pharmacological and Predicted Activities of Natural Azo Compounds[J]. Natural Products and Bioprospecting, 2017, 7(1): 151-169.

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http://npb.kib.ac.cn/EN/10.1007/s13659-016-0117-3 OR http://npb.kib.ac.cn/EN/Y2017/V7/I1/151

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