Indole Alkaloids Inhibiting Neural Stem Cell from <i>Uncaria rhynchophylla</i>

doi:10.1007/s13659-017-0141-y

Natural Products and Bioprospecting

2017, Vol. 7

Issue (5) : 413-419 DOI: 10.1007/s13659-017-0141-y

Original articles

Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla

Xin Wei^1,2, Li-Ping Jiang^2,3, Ying Guo^1,2, Afsar Khan⁴, Ya-Ping Liu¹, Hao-Fei Yu^1,2, Bei Wang^1,2, Cai-Feng Ding^1,2, Pei-Feng Zhu^1,2, Ying-Ying Chen¹, Yun-Li Zhao¹, Yong-Bing Chen³, Yi-Fen Wang¹, Xiao-Dong Luo^1,5

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People's Republic of China;
4. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;
5. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China

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Abstract Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness, cerebrovascular diseases, and nervous disorders in China. Previously, the neuro-protective activities of the alkaloids from U. rhynchophylla were intensively reported. In current work, three new indole alkaloids (1-3), identified as geissoschizic acid (1), geissoschizic acid N₄-oxide (2), and 3β-sitsirikine N₄-oxide (3), as well as 26 known analogues were isolated from U. rhynchophylla. However, in the neural stem cells (NSCs) proliferation assay for all isolated compounds, geissoschizic acid (1), geissoschizic acid N₄-oxide (2), isocorynoxeine (6), isorhynchophylline (7), (4S)-akuammigine N-oxide (8), and (4S)-rhynchophylline N-oxide (10) showed unexpected inhibitory activities at 10μM. Unlike previous neuro-protective reports, as a warning or caution, our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U. rhynchophylla, while the structure-activity relationships of the isolated compounds were discussed also.

Keywords Uncaria rhynchophylla Indole alkaloids NSCs proliferation

Fund:The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support.

Issue Date: 06 February 2018

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	Xin Wei
	Li-Ping Jiang
	Ying Guo
	Afsar Khan
	Ya-Ping Liu
	Hao-Fei Yu
	Bei Wang
	Cai-Feng Ding
	Pei-Feng Zhu
	Ying-Ying Chen
	Yun-Li Zhao
	Yong-Bing Chen
	Yi-Fen Wang
	Xiao-Dong Luo

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Cite this article:

Xin Wei,Li-Ping Jiang,Ying Guo, et al. Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla[J]. Natural Products and Bioprospecting, 2017, 7(5): 413-419.

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http://npb.kib.ac.cn/EN/10.1007/s13659-017-0141-y OR http://npb.kib.ac.cn/EN/Y2017/V7/I5/413

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