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Lyconadins G and H, Two Rare Lyconadin-Type Lycopodium Alkaloids from Lycopodium complanatum |
Jin-Tang Cheng1,3, Zhi-Jun Zhang1, Xiao-Nian Li1, Li-Yan Peng1, Huai-Rong Luo1, Xing-De Wu1, Qin-Shi Zhao1,2 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; 2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China |
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Abstract Two rare lyconadin-type Lycopodium alkaloids, lyconadins G (1) and H (2), together with four known ones (3-6), were isolated from Lycopodium complanatum. The structures were determined on the basis of their spectroscopic analyses, and the absolute configuration of 1 was established by an X-ray crystallographic analysis. It is the first time to establish the absolute configuration of lyconadin-type Lycopodium alkaloid by an X-ray diffraction experiment. In addition, these findings may provide more information for the biosynthesis of lyconadins.
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Keywords
Lycopodium alkaloids
Lycopodium complanatum
Lyconad
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Fund:This work was financially supported by the NSFC-Joint Foundation of Yunnan Province (No.U1502223);the National Natural Science Foundation of China (No.21402212);the Science and Technology Program of Yunnan Province (No.2015FB173),and the CAS "Light of West China" Program and Youth Innovation Promotion Association CAS (X.-D.Wu) |
Issue Date: 31 January 2018
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