Natural Products and Bioprospecting    2017, Vol. 7 Issue (4) : 315-321     DOI: 10.1007/s13659-017-0138-6
Original article |
Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus
Xu-Jie Qin1,2, Tong Shu1,2, Qian Yu1,2, Huan Yan1,2, Wei Ni1,2, Lin-Kun An1,2, Pan-Pan Li1,2
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. Yunnan Key Laboratory of Medicinal Chemistry, Kunming 650201, People's Republic of China
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Abstract  Callisalignenes G-I (1-3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1-3 exhibited cytotoxicity against HCT116 cells with IC50 values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively.
Keywords Callistemon salignus      Myrtaceae      Meroterpenoids      Cytotoxicity     
Fund:This work was financially supported by National Natural Science Foundation of China (Nos. 31600283 and 31570363) and fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (No. P2017-ZZ04) from Kunming Institute of Botany, Chinese Academy of Sciences.
Issue Date: 07 February 2018
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Xu-Jie Qin
Tong Shu
Qian Yu
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Lin-Kun An
Pan-Pan Li
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Xu-Jie Qin,Tong Shu,Qian Yu, et al. Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus[J]. Natural Products and Bioprospecting, 2017, 7(4): 315-321.
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http://npb.kib.ac.cn/EN/10.1007/s13659-017-0138-6     OR     http://npb.kib.ac.cn/EN/Y2017/V7/I4/315
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