Lycoplanines B-D, Three <i>Lycopodium</i> Alkaloids from <i>Lycopodium complanatum</i>

doi:10.1007/s13659-018-0161-2

Natural Products and Bioprospecting

2018, Vol. 8

Issue (3) : 177-182 DOI: 10.1007/s13659-018-0161-2

ORIGINAL ARTICLE

Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum

Zhi-Jun Zhang^1,2, Qin-Feng Zhu^1,2, Jia Su¹, Xing-De Wu¹, Qin-Shi Zhao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

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Abstract A novel C₁₇N Lycopodium alkaloid (LA), lycoplanine B (1), containing an unusual formyl group, along with two new LAs, lycoplanines C (2) and D (3), were isolated from the whole plant of Lycopodium complanatum. Their structures were elucidated by extensive NMR techniques, including 1D-and 2D-NMR experiments, as well as comparing their spectral data with those of the known analogues. A possible biogenetic pathway for 1 was also proposed.

Keywords Lycopodium complanatum Lycoplanines Lycopodium alkaloids Anti-AChE activity

Fund:This work was financially supported by the NSFC-Joint Foundation of Yunnan Province (No.U1502223),the National Natural Science Foundation of China (Nos.81773611 and 21602227),the Science and Technology Program of Yunnan province (Nos.2016FB140 and 2015FB173).

Corresponding Authors: Qin-Shi Zhao E-mail: qinshizhao@mail.kib.ac.cn

Issue Date: 02 June 2018

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Zhi-Jun Zhang,Qin-Feng Zhu,Jia Su, et al. Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum[J]. Natural Products and Bioprospecting, 2018, 8(3): 177-182.

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http://npb.kib.ac.cn/EN/10.1007/s13659-018-0161-2 OR http://npb.kib.ac.cn/EN/Y2018/V8/I3/177

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