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Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity |
| Chuan-Fu DONGa,b, Lei LIUa,b, Huai-Rong LUOa, Xiao-Nian LIa, Zheng-Ye GUANa,b, Yi-Fen WANGa |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract Three new sesquilignans, 1-3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds(1-4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C(1-3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether(4). As a result, isodunnianol(7) exhibited anti-AChE activity with an IC50 value of 13.0 μM.
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| Keywords
Illicium simonsii
sesquilignans
sesquiterpenoid
anti-AChE activity
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| Fund:This work was supported by the National Natural Science Foundation(20872148). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences for measuring NMR, MS, and IR data. |
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Issue Date: 11 February 2018
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