(±)-Zanthonitidine A, a Pair of Enantiomeric Furoquinoline Alkaloids from <i>Zanthoxylum nitidum</i> with Antibacterial Activity

doi:10.1007/s13659-018-0169-7

Natural Products and Bioprospecting

2018, Vol. 8

Issue (5) : 361-367 DOI: 10.1007/s13659-018-0169-7

ORIGINAL ARTICLES

(±)-Zanthonitidine A, a Pair of Enantiomeric Furoquinoline Alkaloids from Zanthoxylum nitidum with Antibacterial Activity

Li-Na Zhao¹, Xi-Xi Guo¹, Shuai Liu², Li Feng¹, Qi-Rui Bi¹, Zhe Wang¹, Ning-Hua Tan¹

1 Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China;
2 Faculty of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223001, China

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Abstract A pair of new enantiomeric furoquinoline alkaloids, (±)-zanthonitidine A (1), together with nine known ones (2-10) were isolated from the radix of Zanthoxylum nitidum. Their chemical structures were elucidated based on the extensive spectroscopic analysis. The racemic mixture of 1 was separated by chiral column chromatography, and the absolute configurations of (+)-1 and (-)-1 were determined by the comparison of experimental and calculated electronic circular dichroism spectra. Antibacterial activities of compounds 1-9 were evaluated, and compounds (+)-1, (-)-1, 3, 7 and 8 showed antibacterial activities against Bacillus subtilis, Enterococcus faecalis or Staphylococcus aureus.

Keywords Zanthoxylum nitidum Furoquinoline alkaloids Zanthonitidine A Antibacterial activity

Fund:This work was supported by the National Natural Science Foundation of China (31470428, 21702231), the National New Drug Innovation Major Project of China (2017ZX09309027), the Program for Jiangsu Province Innovative Research Team, the Fund for Introduction of High-level Talents from China Pharmaceutical University and the Fundamental Research Funds for the Central Universities (2632017PY19).

Corresponding Authors: Zhe Wang, Ning-Hua Tan E-mail: wangzhe@cpu.edu.cn;nhtan@cpu.edu.cn

Issue Date: 19 September 2018

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Li-Na Zhao,Xi-Xi Guo,Shuai Liu, et al. (±)-Zanthonitidine A, a Pair of Enantiomeric Furoquinoline Alkaloids from Zanthoxylum nitidum with Antibacterial Activity[J]. Natural Products and Bioprospecting, 2018, 8(5): 361-367.

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http://npb.kib.ac.cn/EN/10.1007/s13659-018-0169-7 OR http://npb.kib.ac.cn/EN/Y2018/V8/I5/361

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