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Three New Indole Alkaloids from Tabernaemontana divaricata |
| Yan Deng1,2,3, Mei-Fen Bao1,3, Bao-Bao Shi1,2,3, Jing Wu1,3, Xiang-Hai Cai1,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China |
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Abstract Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines(IC50>20 μM).
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| Keywords
Tabernaemontana divaricata
Monoterpene indole alkaloids
3α-hydroxymethyl-ibogamine
3α-acetatemethoxyl-ibogamine
16α-hydroxyl-ibogamine
Apocynaceae
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| Fund:This project was financially supported by the Applied Basic Research Programs of Yunnan Province (No. 2016FA030) and the National Natural Science Foundation of China (31370377). |
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Corresponding Authors:
Xiang-Hai Cai
E-mail: xhcai@mail.kib.ac.cn
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Issue Date: 02 June 2018
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