| ORIGINAL ARTICLES |
|
|
|
|
|
Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch |
| Jun Wang, Xian-Hua Meng, Tian Chai, Jun-Li Yang, Yan-Ping Shi |
| CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China |
|
|
|
|
Abstract Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1-3, two aconitinetype diterpenoid alkaloids 4-5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Compounds 1 and 7 were new compounds, and their chemical structures were determined on the basis of nuclear magnetic resonance (NMR) spectra and mass spectrometry analysis. A ThT assay revealed that compound 2 showed significant disaggregation potency on the Aβ1-42 aggregates.
|
| Keywords
Aconitum pendulum
Alkaloids
Lignan
Anti-AD activity
|
| Fund:This work was financially supported by National Natural Science Foundation of China (Nos. 81673325 and 81711540311), the International Partnership Program of CAS (No. 153631KYSB20160004), Gansu Province Key International S&T Cooperation Project (No. 18YF1WA127), and CAS Pioneer Hundred Talents Program. |
|
Corresponding Authors:
Jun-Li Yang, Yan-Ping Shi
E-mail: yangjl@licp.cas.cn;shiyp@licp.cas.cn
|
|
Issue Date: 11 December 2019
|
|
|
1. P.G. Xiao, F.P. Wang, F. Gao, L.P. Yan, D.L. Chen, Y. Liu, Acta Phytotaxon. Sin. 44, 1-46 (2006)
2. M. El-Shazly, C.J. Tai, T.Y. Wu, D. Csupor, J. Hohmann, F.R. Chang, Y.C. Wu, J. Food Drug Anal. 24, 29-45 (2016)
3. Y.J. Wang, C.J. Zeng, Z. Yao, J. Zhang, Y. Zhang, F. Zhang, Chin. Tradit. Herb. Drugs 41, 347-351 (2010)
4. D.G. Barceloux, Medical Toxicology of Natural Substances, Foods, Fungi, Medicinal Herbs, Toxic Plants, and Venomous Animals (Wiley, Hoboken, 2008), pp. 736-742
5. C.C. Lin, T.Y.K. Chan, J.F. Deng, Ann. Emerg. Med. 43, 574-579 (2004)
6. F. Moritz, P. Compagnon, I.G. Kaliszczak, Y. Kaliszczak, V. Caliskan, C. Girault, Clin. Toxicol. 43, 873-876 (2005)
7. S.W. Smith, R.R. Shah, C.A. Herzog, Ann. Emerg. Med. 45, 100-101 (2005)
8. T.Y.K. Chan, Toxins 6, 2605-2611 (2014)
9. A.M. Bello-Ramirez, J. Buendia-Orozco, A.A. Nava-Ocampo, Fundam. Clin. Pharmacol. 17, 575-580 (2003)
10. S.R. Breining, Curr. Top. Med. Chem. 4, 609-629 (2004)
11. Y.Z. Zhu, K.H. Tan Benny, B.H. Bay, C.H. Liu, Natural Products:Essential Resources for Human Survival (World Scientific, Singapore, 2007), p. 85100 (2007).
12. H.L. Jiang, W. Ha, J.L. Yang, Y.P. Shi, Phytochem. Lett. 17, 1-5 (2016)
13. J.L. Yang, Y.M. Zhao, Y.P. Shi, Nat. Prod. Bioprospect. 6, 211-216 (2016)
14. X.Y. Xie, R. Wang, Y.P. Shi, Planta Med. 78, 1010-1014 (2012)
15. J.L. Yang, Y.P. Shi, Phytochemistry 76, 124-132 (2012)
16. J.L. Yang, R. Wang, L.L. Liu, Y.P. Shi, Planta Med. 77, 362-367 (2011)
17. X.H. Meng, Z.B. Jiang, C.G. Zhu, Q.L. Guo, C.B. Xu, J.G. Shi, Chin. Chem. Lett. 27, 993-1003 (2016)
18. A. Estévez-braun, R. Estévez-reyes, J.A. González-pérez, A.G. González, J. Nat. Prod. 58, 887-892 (1995)
19. Z.C. Fan, Z.Q. Zhang, J Chem. Crystallogr. 38, 635 (2008)
20. J. Chen, Res. Pract. Chin. Med. 27, 33-35 (2013)
21. Z.G. Chen, H.C. Wang, A.N. Lao, B.D. Wang, S.H. Hong, Chin. J. Org. Chem. 9, 490-497 (1989)
22. T.P. Yin, L. Cai, J.M. He, J.W. Dong, H.X. Fang, H. Zhou, Z.T. Ding, J. Asian Nat. Prod. Res. 16, 345-350 (2014)
23. S.W. Pelletier, N.V. Mody, R.S. Sawhney, Can. J. Chem. 57, 1652-1655 (1979)
24. J.C. Holzbach, L.M.X. Lopes, Molecules 15, 9462-9472 (2010)
25. T. Chai, X.-B. Zhao, W.-F. Wang, Y. Qiang, X.-Y. Zhang, J.-L. Yang, Molecules 23, 2663 (2018)
26. J. Wang, J.-L. Yang, P.-P. Zhou, X.-H. Meng, Y.-P. Shi, J. Agric. Food Chem. 65, 5926-5934 (2017) |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
