Secondary Metabolites Produced by an Endophytic Fungus <i>Pestalotiopsis microspora</i>

doi:10.1007/s13659-019-00225-0

Natural Products and Bioprospecting

2019, Vol. 9

Issue (6) : 411-418 DOI: 10.1007/s13659-019-00225-0

ORIGINAL ARTICLES

Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

G. R. Nalin Rathnayake¹, N. Savitri Kumar¹, Lalith Jayasinghe¹, Hiroshi Araya², Yoshinori Fujimoto^1,2

1 National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka;
2 School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan

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Abstract An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1-5, 7 and 8 from P. microspora are reported here for the first time.

Keywords Pestalotiopsis microspora Manilkara zapota Endophyte Pitholide E Pestalotin

Fund:Financial support from the National Research Council (Research Grant NRC 12-032) is gratefully acknowledged.

Corresponding Authors: Lalith Jayasinghe E-mail: ulbj2003@yahoo.com,lalith.ja@nifs.ac.lk

Issue Date: 11 December 2019

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G. R. Nalin Rathnayake,N. Savitri Kumar,Lalith Jayasinghe, et al. Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora[J]. Natural Products and Bioprospecting, 2019, 9(6): 411-418.

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http://npb.kib.ac.cn/EN/10.1007/s13659-019-00225-0 OR http://npb.kib.ac.cn/EN/Y2019/V9/I6/411

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