Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from <i>Datura stramonium</i> L.

doi:10.1007/s13659-013-0010-2

Natural Products and Bioprospecting

2013, Vol. 3

Issue (1) : 20-23 DOI: 10.1007/s13659-013-0010-2

Regular Article

Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.

Han-Jing CHEN, Takayoshi AWAKAWA, Jie-Yin SUN, Toshiyuki WAKIMOTO, Ikuro ABE

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

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Abstract The treatment of fungi with DNA methyltransferase (DNMT) and/or histone deacetylase (HDAC) inhibitors is a promising way to activate secondary metabolite biosynthetic pathways that are dormant under normal conditions. In this study, we included an HDAC inhibitor, suberoylanilide hydroxamic acid (SBHA), in the culture medium of endophytic fungi isolated from the medicinal plant Datura stramonium L. The production of two compounds was induced in the culture supplemented with SBHA, and their structures were determined to be the fusaric acid derivatives 5-butyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid and 5-(but-9-enyl)-6-oxo-1,6-dihydropyridine-2-carboxylic acid. The result confirmed that the use of chemical epigenetic modifiers is an effective technique for promoting the expression of silent biosynthetic pathways to produce unique secondary metabolites.

Keywords endophyte epigenetic modifier biosynthesis fusaric acid

Issue Date: 11 February 2018

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	Han-Jing CHEN
	Takayoshi AWAKAWA
	Jie-Yin SUN
	Toshiyuki WAKIMOTO
	Ikuro ABE

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Han-Jing CHEN,Takayoshi AWAKAWA,Jie-Yin SUN, et al. Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.[J]. Natural Products and Bioprospecting, 2013, 3(1): 20-23.

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http://npb.kib.ac.cn/EN/10.1007/s13659-013-0010-2 OR http://npb.kib.ac.cn/EN/Y2013/V3/I1/20

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