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Antitumor Research on Artemisinin and Its Bioactive Derivatives |
| Yunqin Zhang1,2, Guowei Xu1,2, Shuqun Zhang1, Dong Wang1, P. Saravana Prabha1, Zhili Zuo1,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of the Chinese Academy of Sciences, Beijing 100049, China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, China |
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Abstract Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisininrelated compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.
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| Keywords
Artemisinin
Artemisinin derivatives
Antitumor
Activity
Mechanism
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| Fund:This work was financially supported by CAS "Light of West China" Program ([2014]91 to Z.Z.), the Basic Research Plan of Yunnan Provincial Science and Technology Department (grant number 2014FA042), CAS Strategic biological resources service network (ZSTH-021),and the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No. XDA12030206. |
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Corresponding Authors:
Zhili Zuo,zuozhili@mail.kib.ac.cn
E-mail: zuozhili@mail.kib.ac.cn
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Issue Date: 28 August 2018
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