Triterpenoid Saponins from the Seeds of <i>Aesculus chinensis</i> and Their Cytotoxicities

doi:10.1007/s13659-017-0148-4

Natural Products and Bioprospecting

2018, Vol. 8

Issue (1) : 47-56 DOI: 10.1007/s13659-017-0148-4

ORIGINAL ARTICLES

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang, An Liu

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

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Abstract Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC₅₀ values ranging from 7.1 to 31.3 μM.

Keywords Aesculus chinensis Triterpenoid saponins Chemical structures Anti-tumor activity

Corresponding Authors: An Liu E-mail: la62@163.com

Issue Date: 27 February 2018

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	Jin-Tang Cheng
	Shi-Tao Chen
	Cong Guo
	Meng-Jiao Jiao
	Wen-Jin Cui
	Shu-Hui Wang
	Zhe Deng
	Chang Chen
	Sha Chen
	Jun Zhang
	An Liu

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Jin-Tang Cheng,Shi-Tao Chen,Cong Guo, et al. Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities[J]. Natural Products and Bioprospecting, 2018, 8(1): 47-56.

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http://npb.kib.ac.cn/EN/10.1007/s13659-017-0148-4 OR http://npb.kib.ac.cn/EN/Y2018/V8/I1/47

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