Abietane Diterpernoids from the Roots of <i>Euphorbia ebracteolata</i>

doi:10.1007/s13659-018-0159-9

Natural Products and Bioprospecting

2018, Vol. 8

Issue (2) : 131-135 DOI: 10.1007/s13659-018-0159-9

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Abietane Diterpernoids from the Roots of Euphorbia ebracteolata

Yuan-Liang Ma^1,2, Xiao-Han Tang¹, Wen-Juan Yuan^1,3, Xiao Ding¹, Ying-Tong Di¹, Xiao-Jiang Hao¹

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

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Abstract A new ent-abietane diterpernoid, named ebracteolata D (1), along with 11 known analogues, was isolated from the roots of Euphorbia ebracteolata Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis and molecular modeling. Cytotoxicity of compounds 1-12 was evaluated as well as the effect on the NF-κB pathway. Among them, compound 12, jolkinolide B, displayed broad inhibitory effects against proliferation of tumor cell lines. Mechanistic studies indicated that the compound 12 can inhibit TNF-α induced NF-κB activation, thereby inducing tumor cell apoptosis.

Keywords Euphorbiaceae Euphorbia ebracteolata Abietane diterpernoid Cytotoxic activity

Fund:This research was supported financially by grants from the National Science Foundation of China (21432010, 81573323, and 31770392), Technological Leading Talent Project of Yunnan Province (2015HA020), Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences (CAM201402, CAM201302).

Corresponding Authors: Ying-Tong Di, Xiao-Jiang Hao E-mail: diyt@mail.kib.ac.cn;haoxj@mail.kib.ac.cn

Issue Date: 26 April 2018

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Yuan-Liang Ma,Xiao-Han Tang,Wen-Juan Yuan, et al. Abietane Diterpernoids from the Roots of Euphorbia ebracteolata[J]. Natural Products and Bioprospecting, 2018, 8(2): 131-135.

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http://npb.kib.ac.cn/EN/10.1007/s13659-018-0159-9 OR http://npb.kib.ac.cn/EN/Y2018/V8/I2/131

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