Koninginins N-Q, Polyketides from the Endophytic Fungus <i>Trichoderma koningiopsis</i> Harbored in <i>Panax notoginseng</i>

doi:10.1007/s13659-015-0085-z

Natural Products and Bioprospecting

2016, Vol. 6

Issue (1) : 49-55 DOI: 10.1007/s13659-015-0085-z

Original article

Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

Kai Liu¹, Ya-Bin Yang², Jin-Lian Chen³, Cui-Ping Miao¹, Qiang Wang¹, Hao Zhou², You-Wei Chen¹, Yi-Qing Li¹, Zhong-Tao Ding², Li-Xing Zhao¹

1. Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming 650091, People's Republic of China;
2. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China;
3. School of Energy and Environment Science, Yunnan Normal University, Kunming 650092, People's Republic of China

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Abstract Four new fungal polyketides named koninginins N-Q (1-4), together with four known analogues (5-8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity.

Keywords Trichoderma koningiopsis Polyketide Antifungal activity Bioactivity assay Koninginin

Fund:This work was supported partly by grants from the National Natural Science Foundation of China (Nos.81360480,21262041 and 81460536)

Issue Date: 08 February 2018

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	Kai Liu
	Ya-Bin Yang
	Jin-Lian Chen
	Cui-Ping Miao
	Qiang Wang
	Hao Zhou
	You-Wei Chen
	Yi-Qing Li
	Zhong-Tao Ding
	Li-Xing Zhao

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Kai Liu,Ya-Bin Yang,Jin-Lian Chen, et al. Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng[J]. Natural Products and Bioprospecting, 2016, 6(1): 49-55.

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http://npb.kib.ac.cn/EN/10.1007/s13659-015-0085-z OR http://npb.kib.ac.cn/EN/Y2016/V6/I1/49

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