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The Bioactive Secondary Metabolites from Talaromyces species
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Ming-Ming Zhai, Jie Li, Chun-Xiao Jiang, Yan-Ping Shi, Duo-Long Di, Phillip Crews, Quan-Xiang Wu
Natural Products and Bioprospecting. 2016, 6 (1): 1-24.
DOI: 10.1007/s13659-015-0081-3
The focus of this review is placed on the chemical structures from the species of the genus Talaromyces reported with reference to their biological activities. 221 secondary metabolites, including 43 alkaloids and peptides, 88 esters, 31 polyketides, 19 quinones, 15 steroid and terpenoids, and 25 other structure type compounds, have been included, and 66 references are cited.
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Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata
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Lai-Bin Zhang, Chun Lei, Li-Xin Gao, Jing-Ya Li, Jia Li, Ai-Jun Hou
Natural Products and Bioprospecting. 2016, 6 (1): 25-30.
DOI: 10.1007/s13659-015-0082-2
Three new C-methylated and isoprenylated chalcone derivatives, dentichalcones A-C (1-3), together with six known compounds (4-9), were isolated from the twigs and leaves of Macaranga denticulata. Their structures were elucidated by spectroscopic analysis, including 1D, 2D NMR, and MS data. The known compounds, (2E)-1-(5,7-dihydroxy-2,2,6-trimethyl-2H-benzopyran-8-yl)-3-(4-methoxyphenyl)-2-propen-1-one (4), (2E)-1-(5,7-dihydroxy-2,2-dimethyl-2H-benzopyran-8-yl)-3-phenyl-2-propen-1-one (5), laxichalcone (6), macarangin (7), bonanniol A (8), and bonannione A (9), showed inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) in vitro. Graphical Abstract Three new C-methylated and isoprenylated chalcone derivatives, dentichalcones A-C (1-3), together with six known compounds, were isolated from the twigs and leaves of Macaranga denticulata. Some compounds showed inhibitory activities against PTP1B in vitro.
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Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest
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Qingxi Su, Peggy J. Brodie, Yixi Liu, James S. Miller, Naina M. Andrianjafy, Rabodo Antsiferana, Vincent E. Rasamison, David G. I. Kingston
Natural Products and Bioprospecting. 2016, 6 (1): 31-39.
DOI: 10.1007/s13659-015-0083-1
Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1-3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1-3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8, 10.2 and 2.0 lM, respectively.
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Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng
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Kai Liu, Ya-Bin Yang, Jin-Lian Chen, Cui-Ping Miao, Qiang Wang, Hao Zhou, You-Wei Chen, Yi-Qing Li, Zhong-Tao Ding, Li-Xing Zhao
Natural Products and Bioprospecting. 2016, 6 (1): 49-55.
DOI: 10.1007/s13659-015-0085-z
Four new fungal polyketides named koninginins N-Q (1-4), together with four known analogues (5-8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity.
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