Formosins A-F: Diterpenoids with Anti-microbial Activities from <i>Excoecaria formosana</i>

doi:10.1007/s13659-016-0086-6

Natural Products and Bioprospecting

2016, Vol. 6

Issue (1) : 57-61 DOI: 10.1007/s13659-016-0086-6

Original article

Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

Bing-Dong Lin, Bin Zhou, Lei Dong, Yan Wu, Jian-Min Yue

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China

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Abstract Three new halimane-type diterpenoids formosins A-C (1-3), and three clerodane-type diterpenoids formosins D-F (4-6), were isolated from the twigs of Excoecaria formosana. Their structures were assigned on the basis of spectroscopic data analysis. Compounds 1 and 4 showed moderate anti-microbial activities against Bacillus subtilis (MIC=50 and 50 lg/mL, respectively). Compound 6 exhibited moderate anti-microbial activities against two strains of Helicobacter pylori (Hp-SS1 and ATCC 43504) with MIC values of 50 and 50 lg/mL, respectively.

Keywords Excoecaria formosana Halimane-type Clerodane-type Diterpenoid Anti-microbial

Fund:Financial support from the National Natural Science Foundation (Grant No.U1302222;81321092) of the People's Republic of China is gratefully acknowledged.We thank Prof.S.-M.Huang of Hainan University for the identification of the plant material

Issue Date: 08 February 2018

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Bing-Dong Lin,Bin Zhou,Lei Dong, et al. Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana[J]. Natural Products and Bioprospecting, 2016, 6(1): 57-61.

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http://npb.kib.ac.cn/EN/10.1007/s13659-016-0086-6 OR http://npb.kib.ac.cn/EN/Y2016/V6/I1/57

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