| Regular Article |
|
|
|
|
|
Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii |
| Rui ZHANa,b, Xue DUa, Jia SUa, Xiao-Nian LIa, Wei-Guang WANGa, Cheng-Qin LIANGa, Jian-Hong YANGa, Yan LIa, Jian-Xin PUa, Han-Dong SUNa |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China |
|
|
|
|
Abstract Three new ent-kauranoids, isorosthornins A-C(1-3), and a new natural product, dihydroponicidin(4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines.
|
| Keywords
Isodon rosthornii
ent-kaurane diterpenoid
cytotoxicity
|
| Fund:This work was supported financially by the NSFC-Joint Foundation of Yunnan Province(No. U0832602 to H. D. Sun), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), the Science and Technology Program of Yunnan Province(No. 2008IF010 and 2008CD162), the NSFC(No. 81172939 to J. X. Pu), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No. 2010KIBA05 to J. X. Pu). |
|
Issue Date: 11 February 2018
|
|
|
| [1] |
Sun, H. D.; Xu, Y. L.; Jiang, B. "Diterpenoids from Isodon Species". Science Press, Beijing, 2001.
|
| [2] |
Sun, H. D.; Huang, S. X.; Han, Q. B. Nat. Prod. Rep. 2006, 23, 673-698.
|
| [3] |
Academia Sinca. "Botany of China". Science Publishing House, Beijing, 1979.
|
| [4] |
(a) Hu, K.; Dong, A. J.; Kobayashi, H.; Iwasaki, S.; Yao, X. S. Plant Deriv. Antimycotics 2003, 525-549; (b) Kubo, I.; Xu, Y. L.; Shimizu, K. Phytother. Res. 2004, 18, 180-183; (c) Li, G. Y.; Wang, Y. L. Yaoxue Xuebao 1984, 19, 590-592; (d) Xu, Y. L.; Li, Z. Q. Yunnan Zhiwu Yanjiu 1998, 20, 97-101; (e) Xu, Y. L.; Ma, Y. B. Phytochemistry 1989, 28, 3235-3237.
|
| [5] |
(a) Wang, X. R.; Wang, H. P.; Hu, H. P.; Sun, H. D.; Wang, S. Q.; Ueda, S.; Kuroda, Y.; Fujita, T. Phytochemistry 1995, 38, 921-926; (b) Fujita, E.; Taoka, M.; Shibuya, M.; Fujita, T.; Shingu, T., J. Chem. Soc., Perkin Trans. 11973, 2277-2281.
|
| [6] |
Hou, A. J.; Li, M. L.; Jiang, B.; Lin, Z. W.; Ji, S. Y.; Zhou, Y. P.; Sun, H. D. J. Nat. Prod. 2000, 63, 599-601.
|
| [7] |
Gao, Y. H.; Wu, S. H.; Zhong, R. J.; Li, G. Y. Zhongcaoyao 1996, 27, 579-580.
|
| [8] |
Gao, Y. H.; Wu, S. H.; Cheng, Y. Zhongcaoyao 1999, 30, 407-409.
|
| [9] |
Monks, A.; Scudiero, D.; Skehan, P.; Shoemaker, R.; Paull, K.; Vistica, D.; Hose, C.; Langley, P. J. Natl. Cancer Inst. 1991, 83, 757-766.
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
