Antifeedant and Antiviral Diterpenoids from the Fresh Roots of <i>Euphorbia jolkinii</i>

doi:10.1007/s13659-014-0009-3

Natural Products and Bioprospecting

2014, Vol. 4

Issue (2) : 91-100 DOI: 10.1007/s13659-014-0009-3

Original article

Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii

Chun-Shuai Huang^1,2, Shi-Hong Luo¹, Yao-Lan Li³, Chun-Huan Li¹, Juan Hua¹, Yan Liu¹, Shu-Xi Jing¹, Ying Wang¹, Min-Jie Yang¹, Sheng-Hong Li¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. Graduate University of Chinese Academy of Sciences, Beijing 100049, China;
3. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China

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Abstract The perennial herbaceous plant Euphorbia jolkinii(Euphorbiaceae) is a noxious weed widely distributed in the grasslands of northwestern Yunnan and has greatly threatened the local biodiversity. Phytochemical investigation on the fresh roots of E. jolkinii afforded six new diterpenoids 1, 2, 4-6, and 8, together with fifteen known diterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR and other spectroscopic methods. Casbane, lathyrane, abietane, and ent-kaurane diterpenoids were reported from this plant for the first time. Selected compounds were evaluated for their antifeedant and anti-RSV(respiratory syncytial virus) activities. Compound 2 and ingenol(3) exhibited moderate antifeedant activity against a generalist insect herbivore, Spodoptera exigua, with EC₅₀ values of 17.88 and 17.71 lg/cm² respectively. Compound 19 showed significant anti-RSV activity, with 50% inhibition(IC₅₀) value of 10.0 μM and selective index of 8.0. Compounds 1 and 2 were less active against RSV virus, both with IC₅₀ value of 25 μM, and with selective indices of 1.0 and 3.2 respectively. These findings provided new evidence for the biological functions and utilization of the diversified diterpenoid metabolites in the roots of this rich but harmful plant.

Keywords Euphorbia jolkinii Diterpenoids Antifeedant activity Antiviral activity

Fund:This research was supported financially by the National Natural Science Foundation of China(31200263), the Youth Innovation Promotion association of Chinese Academy of Sciences(awarded to Shi-Hong Luo), the''Western Light''Program of Chinese Academy of Sciences(awarded to Shi-Hong Luo), and the''Hundred Talents Program''of Chinese Academy of Sciences(awarded to Sheng-Hong Li).

Issue Date: 11 February 2018

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	Chun-Shuai Huang
	Shi-Hong Luo
	Yao-Lan Li
	Chun-Huan Li
	Juan Hua
	Yan Liu
	Shu-Xi Jing
	Ying Wang
	Min-Jie Yang
	Sheng-Hong Li

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Chun-Shuai Huang,Shi-Hong Luo,Yao-Lan Li, et al. Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii[J]. Natural Products and Bioprospecting, 2014, 4(2): 91-100.

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http://npb.kib.ac.cn/EN/10.1007/s13659-014-0009-3 OR http://npb.kib.ac.cn/EN/Y2014/V4/I2/91

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