Antifungalmycin,an antifungal macrolide from <i>Streptomyces padanus</i> 702

doi:10.1007/s13659-011-0037-1

Natural Products and Bioprospecting

2012, Vol. 2

Issue (1) : 41-45 DOI: 10.1007/s13659-011-0037-1

Regular Article

Antifungalmycin,an antifungal macrolide from Streptomyces padanus 702

Yi-Fen WANG^a, Sai-Jin WEI^b, Zhi-Ping ZHANG^b, Tong-He ZHAN^b, Guo-Quan TU^b

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
b China Biological Science and Engineering College of Jiangxi Agriculture University, Nanchang Key Laboratory of Fermentation Application Technology, Nanchang 330045, China

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Abstract Two polyene macrolide antibiotics: antifungalmycin(1) and fungichromin(2) were isolated from the culture mycelia of Streptomyces padanus 702 via bioactivity-guided fractionation using various chromatographic procedures. Their structures were elucidated on the basis of spectral analysis, and 1 is a new polyene macrolide. Compounds 1 and 2 showed significant inhibition against Gibberella zeae with EC₅₀ values of 26.71 and 2.21 μg/mL, Fusicoccum sp. (plantain head blight) with EC₅₀ values of 23.4 and 3.17 μg/mL, Mucor ssp. 8894 with EC₅₀ values of 28.80 and 2.11 μg/mL, Ustilaginoidea virens with EC₅₀ values of 26.72 and 0.21 μg/mL, respectively. This shows that the microbial secondary metabolites 1 and 2 have the potential to be developed as agricultural fungicides for use against G. zeae, Fusicoccum sp., Mucor ssp. 8894, and U. virens.

Keywords antifungalmycin Streptomyces padanus 702 polyene macrolide biocontrol antifungal activity phytopathogen

Fund:This work was supported by the National Natural Science Foundation(20872148 and 30960011), and the Natural Science Foundation of Jiangxi Province(2009GZN0030). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences for measuring NMR, MS, and IR data.

Issue Date: 11 February 2018

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Yi-Fen WANG,Sai-Jin WEI,Zhi-Ping ZHANG, et al. Antifungalmycin,an antifungal macrolide from Streptomyces padanus 702[J]. Natural Products and Bioprospecting, 2012, 2(1): 41-45.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0037-1 OR http://npb.kib.ac.cn/EN/Y2012/V2/I1/41

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