Chemistry and biology of marine-derived <i>Trichoderma</i> metabolites

doi:10.1007/s13659-024-00433-3

Natural Products and Bioprospecting

2024, Vol. 14

Issue (3) : 14-14 DOI: 10.1007/s13659-024-00433-3

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Chemistry and biology of marine-derived Trichoderma metabolites

Yin-Ping Song, Nai-Yun Ji

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, People's Republic of China

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Abstract Marine-derived fungi of the genus Trichoderma have been surveyed for pharmaceuticals and agrochemicals since 1993, with various new secondary metabolites being characterized from the strains of marine animal, plant, sediment, and water origin. Chemical structures and biological activities of these metabolites are comprehensively reviewed herein up to the end of 2022 (covering 30 years). More than 70 strains that belong to at least 18 known Trichoderma species have been chemically investigated during this period. As a result, 445 new metabolites, including terpenes, steroids, polyketides, peptides, alkaloids, and others, have been identified, with over a half possessing antimicroalgal, zooplankton-toxic, antibacterial, antifungal, cytotoxic, anti-inflammatory, and other activities. The research is highlighted by the molecular diversity and antimicroalgal potency of terpenes and steroids. In addition, metabolic relevance along with co-culture induction in the production of new compounds is also concluded. Trichoderma strains of marine origin can transform and degrade heterogeneous molecules, but these functions need further exploration.

Keywords Trichoderma Metabolite Terpene Polyketide Peptide Bioactivity

Fund:The preparation of this review and our related research were financially supported by the National Natural Science Foundation of China (42076096 and 31670355), the Taishan Scholar Project Special Funding (tsqn201909164), and the Youth Innovation Promotion Association of the CAS (2023222).

Corresponding Authors: Nai-Yun Ji,E-mail:nyji@yic.ac.cn E-mail: nyji@yic.ac.cn

Issue Date: 14 June 2024

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Yin-Ping Song,Nai-Yun Ji. Chemistry and biology of marine-derived Trichoderma metabolites[J]. Natural Products and Bioprospecting, 2024, 14(3): 14-14.

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http://npb.kib.ac.cn/EN/10.1007/s13659-024-00433-3 OR http://npb.kib.ac.cn/EN/Y2024/V14/I3/14

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