| ORIGINAL ARTICLES |
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Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others |
| Zhe-Wei Yu1,2, Bang-Ping Cai3, Su-Zhi Xie4, Yi Zhang1, Wen-Hui Wang1, Shun-Zhi Liu1, Yan-Lin Bin1, Qi Chen1, Mei-Juan Fang1, Rong Qi2, Ming-Yu Li1, Ying-Kun Qiu1 |
1 School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China;
2 School of Basic Medical Sciences, Peking University, Beijing 100191, China;
3 Xiamen Botanical Garden, Xiamen 361003, Fujian, China;
4 Xiamen Medical College Affiliated Haicang Hospital, Xiamen 361026, China |
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Abstract In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.
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| Keywords
Agathis dammara
Lignans
Terpenes
Hypoglycaemic
Glucose uptake
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| Fund:This work was financially supported by Project XWZY-2023-0303 supported by Traditional Chinese Medicine Foundation of Xiamen. |
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Corresponding Authors:
Ming-Yu Li,E-mail:limingyu@xmu.edu.cn;Ying-Kun Qiu,E-mail:qyk@xmu.edu.cn
E-mail: limingyu@xmu.edu.cn;qyk@xmu.edu.cn
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Issue Date: 14 June 2024
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