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Neolignans from Selaginella moellendorffii |
Jing-Xian Zhuo1, Yue-Hu Wang1, Xing-Li Su2, Ren-Qiang Mei1, Jun Yang1, Yi Kong2, Chun-Lin Long1,3 |
1. Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; 2. School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, China; 3. College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China |
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Abstract Two new neolignans selaginellol (1) and selaginellol 4'-O-b-D-glucopyranoside (2), together with seven known compounds (3-9), were isolated from the whole plant of Selaginella moellendorffii. The structures of the new isolates were determined through spectroscopic data analysis. Compounds 1-9, as well as compounds 10-18 previously isolated from the species, were measured for the activity against platelet aggregation induced by ADP or collagen. Three neoligans (8, 11, and 12), one flavanone (14), and one alkaloid (16) showed inhibitory activity against ADP-or collagen-induced platelet aggregation as compared with tirofiban. The dihydrobenzofuran neolignans (8, 11, and 12) are more potent than the benzofuran neolignan (13) and other types of neolignans (1-7). Glucosidation of the dihydrobenzofuran neolignans (11 and 12) is helpful for the activity.
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Keywords
Selaginellaceae
Selaginella moellendorffii
Lignans
Antiplatelet
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Fund:This work was funded by the Ministry of Science&Technology of China (2012FY110300);the National Natural Science Foundation of China (3116140345),and the Minzu University of China (YLDX01013,2015MDTD16C) |
Issue Date: 08 February 2018
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