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Furanocembranoid from the Okinawan soft coral Sinularia sp. |
| Misaki Nagasaka1, Kazuki Tani1, Keisuke Nishikawa2, Riri Kinjo1, Takahiro Ishii1 |
1 Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa 903-0213, Japan;
2 Department of Chemistry, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan |
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Abstract One new furanocembranoid diterpene, 11-hydroxy-Δ12(13)-pukalide (1), along with six known secondary metabolites, 11-acetoxy-Δ12(13)-pukalide (2), 13α-acetoxypukalide (3), pukalide (4), 3α-methoxyfuranocembranoid (5), Δ9(15)-africanene (6), and methyl (5'E)-5-(2',6'-dimethylocta-5',7'-dienyl)furan-3-carboxylate (7) were isolated from the Okinawan soft coral Sinularia sp. Their chemical structures were elucidated based on spectroscopic analysis (FTIR, NMR, and HRESIMS), and the relative stereochemistry of 1 was determined by NOESY experiments and acetylation, which yielded derivative 2. In addition, compounds 1 and 7 exhibited toxicity in the brine shrimp lethality test.
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| Keywords
Soft coral
Sinularia sp.
Furanocembranoid
Diterpene
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| Fund:We are grateful to Mr. Masahiro Wada (Faculty of Agriculture, University of the Ryukyus) for his guidance on the collection site of the soft corals. The authors would also like to thank Mr. Shinichi Gima (Center for Research Advancement and Collaboration, University of the Ryukyus) for the measurement of HRESIMS. Finally, we would like to thank Editage (www.editage.com) for English language editing. |
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Corresponding Authors:
Takahiro Ishii
E-mail: ishiit@agr.u-ryukyu.ac.jp
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Issue Date: 12 March 2022
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