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Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum |
| Hao-Yi Li1,2, Bing-Chao Yan1, Li-Xin Wei3, Han-Dong Sun1, Pema-Tenzin Puno1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, People's Republic of China |
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Abstract Three new diterpene alkaloids, tangutidines A-C (1-3), and four known alkaloids (4-7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1-3) were obtained for the first time. The structures of 1-3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.
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| Keywords
Aconitum tanguticum
Amphoteric diterpene alkaloids
Tangutidine
Cytotoxic activity
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| Fund:This project was supported financially by the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502) and the National Natural Science Foundation of China (No. 81673329). Authors are grateful for Dr. Ming Zhang from northwest institute of plateau biology, Chinese Academy of Sciences, for the assistance for obtaining plant materials. |
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Corresponding Authors:
Han-Dong Sun, Pema-Tenzin Puno
E-mail: hdsun@mail.kib.ac.cn;punopematenzin@mail.kib.ac.cn
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Issue Date: 30 July 2021
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