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New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch |
| Qing-Yun Lu1,5, Jia-Hui Zhang1,2, Ying-Yao Li1,3, Xue-Xue Pu1,4, Cui-Shan Zhang1,5, Shuai Liu1,5, Jia-Jia Wan1,5, Ying-Tong Di1, Xiao-Jiang Hao1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 School of Life Sciences, Southwest University, Chongqing 400715, China;
3 Yunnan University, Kunming, People's Republic of China;
4 Yunnan University of Traditional Chinese Medicine, Kunming, People's Republic of China;
5 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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Abstract One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC50 of 31.9 μM.
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| Keywords
Daphniphyllum angustifolium hutch
Secodaphnane-type
Daphnioldhanol A
Cytotoxic activity
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| Fund:This work was financially supported by the National Natural Science Foundation of China (No. 31770392 to YTD), and the Science and Technology Program of Yunnan Province (2018ZF013 to YTD). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, for recorded spectra. |
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Corresponding Authors:
Ying-Tong Di, Xiao-Jiang Hao
E-mail: diyt@mail.kib.ac.cn;haoxj@mail.kib.ac.cn
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Issue Date: 30 July 2021
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