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The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3 |
| Ding-kang Chen1,2,3, Hui-yan Shao1, Liu Yang1,2, Jiang-miao Hu1,2,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 R&D Center of Dr. Plant, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3 University of Chinese Academy of Science, Beijing 100049, China |
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Abstract Dendrobium officinale is a valuable medicinal herb that is widely used in traditional Chinese medicine. The chemical constituents of D. officinale have attracted much attention and a large number of compounds have been reported including many bibenzyl derivatives. 13 bibenzyl derivatives from D. officinale were sent for molecular docking, surface plasmon resonance (SPR) assay and after detection of Mn-SOD and SIRT3 activities in or not in HaCaT cells, it was concluded that bibenzyl derivatives did not directly activate Mn-SOD but promoted SIRT3 proteins. In addition, HaCaT cells were irradiated with UV-B to induce an oxidative stress model in vitro to further verify the effect of bibenzyl derivatives. The results show that bibenzyl derivatives could directly bind to SIRT3, enhance the deacetylation and then activate Mn-SOD, so as to protect UV-B induced skin photoaging.
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| Keywords
Dendrobium officinale
Bibenzyl derivatives
Skin photoaging
Oxidative stress
SIRT3
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| Fund:This work was financially supported by Biological Resources Programme, Chinese Academy of Sciences (Grant No. KFJ-BRP-007-019); National Natural Science Foundation of China (No. 32170407) and Beijing DR PLANT Biotechnology Co., Ltd. |
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Corresponding Authors:
Liu Yang, Jiang-miao Hu
E-mail: yangliu@mail.kib.ac.cn;hujiangmiao@mail.kib.ac.cn
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Issue Date: 12 March 2022
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1. Chen DK, Du ZY, Lin ZR, et al. The chemical compositions of Angelica pubescens oil and its prevention of UV-B radiation-induced cutaneous photoaging. Chem Biodivers. 2018;15:e1800235.
2. Berneburg MH, Plettenberg H, Krutmann J. Photoaging of human skin. Photodermatol Photoimmunol Photomed. 2010;16:239-44.
3. Corsini E, Sangha N, Feldman SR. Epidermal stratification reduces the effects of UVB (but not UVA) on keratinocyte cytokine production and cytotoxicity. Photodermatol Photoimmunol Photomed. 1997;13:147-52.
4. Agin PP. Measuring ultraviolet A protection in sunscreen products. J Am Acad Dermatol. 2017;77:e81.
5. Del Río LA, Sandalio LM, Altomare DA, Zilinskas BA. Mitochondrial and peroxisomal manganese superoxide dismutase:differential expression during leaf senescence. J Exp Bot. 2003;384:923.
6. Gonzalez Herrera KN, Lee J, Haigis MC. Intersections between mitochondrial sirtuin signaling and tumor cell metabolism. Crit Rev Biochem Mol Biol. 2015;50:1-14.
7. Winnik S, Gaul DS, Preitner F, Lohmann C, Weber J, Miranda MX, Liu Y, Tits LJV, Mateos JM, Brokopp CE. Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice:implications for cardiovascular risk factor development. Basic Res Cardiol. 2014;109:399.
8. Tao R, Coleman MC, Pennington JD, et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell. 2010;40:893-904.
9. Zhu Y, Zou X, Dean AE, et al. Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter. Nat Commun. 2019;10:2399.
10. Xia L, Liu X, Guo H, et al. Partial characterization and immunomodulatory activity of polysaccharides from the stem of D. officinale (Tiepishihu) in vitro. J Funct Foods. 2012;4:294-301.
11. Yi Z, Liu Y, Lan XM, et al. Effect of D. officinale extraction on gastric carcinogenesis in rats. J Evid Based Complement Altern Med. 2016;9:e19647.
12. Mtka B, Jyla B, Xbya B, et al. Structural characterization and hypoglycemic effect via stimulating glucagon-like peptide-1 secretion of two polysaccharides from D. officinale. Carbohydr Polym. 2020;241:116326.
13. Ma RJ, Yang L, Bai X, et al. Phenolic constituents with antioxidative, tyrosinase inhibitory and anti-aging activities from Dendrobium loddigesii Rolfe. Nat Prod Bioprospect. 2019;9:329-36.
14. Zhang Y, Wu Z, Liu J, et al. Identification of the core active structure of a Dendrobium officinale polysaccharide and its protective effect against dextran sulfate sodium-induced colitis via alleviating gut microbiota dysbiosis. Food Res Int. 2020;137:109641.
15. Zhao M, Han J. Dendrobium officinale Kimura et Migo ameliorates insulin resistance in rats with diabetic nephropathy. Med Sci Monit Basic Res. 2018;24:84-92.
16. Li M, Yue H, Wang YQ, et al. Intestinal microbes derived butyrate is related to the immunomodulatory activities of Dendrobium officinale polysaccharide. Int J Biol Macromol. 2020;149:717-23.
17. Chen W, Lu J, Zhang J, et al. Traditional uses, phytochemistry, pharmacology, and quality control of D. officinale Kimura et Migo. Front Pharmacol. 2021;12:2026.
18. Liang CY, Liang YM, Liu HZ, et al. Effect of D. officinale on D-galactoseinduced aging mice. Chin J Integr Med. 2017. https://doi.org/10.1007/s11655-016-2631-x.
19. Mai Y, Niu Z, et al. The reparative effect of Dendrobium officinale protocorms against photodamage caused by UV-irradiation in hairless mice. Biol Pharm Bull. 2019;42:728-35.
20. Jujjavarapu SE, Dhagat S, Kurrey V. Identification of novel ligands for therapeutic lipopeptides:daptomycin, surfactin and polymyxin. Curr Drug Targets. 2018;19:1589-98.
21. Nguyen G, Gertz M, Steegborn C. Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. Cell Chem Biol. 2013;20:1375-85.
22. Shivakumar D, Williams J, Wu Y, et al. Prediction of absolute solvation free energies using molecular dynamics free energy perturbation and the OPLS force field. J Chem Theory Comput. 2010;6:1509.
23. Gill BS, Kumar S, Navgeet. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Mol Biol Rep. 2016;43:1-12.
24. Xu H, Gan C, Gao Z, et al. Caffeine targets SIRT3 to enhance SOD2 activity in mitochondria. Front Cell Dev Biol. 2020;8:822.
25. Jia JR, Gong JL, Zeng Y, et al. Bioinspired conductive silk microfiber integrated bioelectronic for diagnosis and wound healing in diabetes. Adv Funct Mater. 2021;31(19):2010461.
26. Hsieh H, Cheng C, Wu S, et al. Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression. J Cell Physiol. 2015;175:156-62.
27. Choudhary C, Kumar C, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009;31:2010461.
28. Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, et al. Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes. Environ Toxicol Pharmacol. 2012;34:926-34.
29. Khan A, Hongliang B, Liu E, et al. Protective effect of neferine against UV-B mediated oxidative damage in human epidermal keratinocytes. J Dermatol Treat. 2018;29:733-41.
30. Yong Y, Tae-Jun K, Jae-Mok L, et al. SOD2 is upregulated in periodontitis to reduce further inflammation progression. Oral Dis. 2018;24:1572-80.
31. Sanderson TH, Raghunayakula S, Kumar R. Release of mitochondrial Opa1 following oxidative stress in HT22 cells. Mol Cell Neurosci. 2015;64:116-22.
32. Kanlayavattanakul M, Lourith N, et al. Biological activity and phytochemical profiles of Dendrobium:a new source for specialty cosmetic materials. Ind Crops Prod. 2018;120:61-70.
33. He L, Su Q, Bai L, et al. Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species. Eur J Med Chem. 2020;204:112530. |
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