| ORIGINAL ARTICLE |
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Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus |
| Jing Fan1, Pai Liu2, Kuan Zhao3, He-Ping Chen1 |
1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China;
2. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China;
3. College of Life Science, Jiangxi Science & Technology Normal University, Nanchang, 330013, China |
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Abstract Three previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated from the cultures of Cordyceps cicadae JXCH1, an entomopathogenic fungus. Their structures and relative configurations were elucidated primarily by NMR spectroscopic analysis. The absolute configurations of 1 and 2 were determined by ECD calculations. Single-crystal X-ray diffraction method was adopted to determine the absolute configuration of 3. Compound 2 is a polycyclic polyketide with an unusual enol ether moiety and a spiro ring. The compounds obtained in this study were subjected to screening their inhibition against the proliferation of the human lung cancer cell line A549 and the production of nitric oxide in murine macrophages RAW264.7.
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| Keywords
Insect pathogenic fungus
Cordyceps cicadae
Steroid
Polyketide
Cyclic dipeptide
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| Fund:This work was financially supported by the National Natural Science Foundation of China (grant number 81903512) and the Fundamental Research Funds for the Central Universities, South-Central Minzu University (Grant Number CPT22033). The authors thank the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central Minzu University for the spectra test. |
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Corresponding Authors:
Kuan Zhao,E-mail:1020160918@jxstnu.edu.cn;He-Ping Chen,E-mail:chenhp@mail.scuec.edu.cn
E-mail: 1020160918@jxstnu.edu.cn;chenhp@mail.scuec.edu.cn
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Issue Date: 26 December 2023
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