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Brown Algae(Phaeophyceae) from the Coast of Madagascar:preliminary Bioactivity Studies and Isolation of Natural Products |
| Marie Pascaline Rahelivao1, Margit Gruner1, Hanta Andriamanantoanina2, Ingmar Bauer1, Hans-Joachim Knölker1 |
1. Department Chemie, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany;
2. Centre National de Recherche sur l'Environnement, MESupRes, BP 1739, 101 Antananarivo, Madagascar |
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Abstract Eight species of brown algae(Phaeophyceae) from the coast of Madagascar have been investigated for their chemical constituents. Fucosterol(3) was obtained as the most abundant compound. The brown alga Sargassum ilicifolium was the source for the first isolation of the terpenoid C27-alcohol 1, 1', 2-trinorsqualenol(1) from marine sources. From S. incisifolium we isolated the highly unsaturated glycolipid 1-O-palmitoyl-2-O-stearidonoyl-3-O-β-D-galactopyranosylglycerol(4) and we report the first full assignment of its 1H and 13C NMR data. Apo-9'-fucoxanthinone(8) along with 24-ketocholesterol(5),(22E)-3β-hydroxycholesta-5, 22-dien-24-one(6), and saringosterol(7) were obtained from Turbinaria ornata. The crude extracts of all eight species of brown algae exhibited a pronounced antimicrobial activity against the Gram-positive bacteria Bacillus cereus, Staphylococcus aureus, and Streptococcus pneumoniae.
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| Keywords
Brown algae
Steroids
Terpenoids
NMR spectroscopy
Antimicrobial activity
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Issue Date: 11 February 2018
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