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Chemistry and bioactivities of natural steroidal alkaloids |
| Mei-Ling Xiang1, Bin-Yuan Hu1, Zi-Heng Qi1, Xiao-Na Wang1, Tian-Zhen Xie1, Zhao-Jie Wang1, Dan-Yu Ma1, Qi Zeng1, Xiao-Dong Luo1,2 |
1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China |
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Abstract Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone acetate (Zytiga®), a blockbuster drug, which has been used for the treatment of prostate cancer. Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities, which are attractive for natural product chemistry and medicinal chemistry communities. This review comprehensively covers the structural classification, isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021, with 363 references being cited.
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| Keywords
Steroidal alkaloids
Chemistry
Bioactivities
Solanaceae
Liliaceae
Apocynaceae
Buxaceae
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| Fund:The authors are grateful to the National Natural Science Foundation of China (32170405) and Yunnan Science and Technology Project (202105AE160006, 2019FY003004) for partial financial support. |
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Corresponding Authors:
Xiao-Dong Luo,E-mail:xdluo@ynu.edu.cn
E-mail: xdluo@ynu.edu.cn
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Issue Date: 12 August 2022
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