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Research Progress of the Antiviral Bioactivities of Natural Flavonoids |
| Lin Wang1, Junke Song1, Ailin Liu1, Bin Xiao2, Sha Li1, Zhang Wen1, Yang Lu1, Guanhua Du1 |
1 Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China;
2 Laboratory of Clinical Pharmacy, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, Ordos 017000, China |
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Abstract Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids, highlights the cellular and molecular mechanisms of natural flavonoids on viruses, and presents the details of most reported flavonoids. Meanwhile, future perspectives on therapeutic applications of flavonoids against viral infections were discussed.
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| Keywords
Antiviral bioactivities
Natural flavonoids
Cellular and molecular mechanisms
Therapeutic applications
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| Fund:The work was supported by CAMS Innovation Fund for Medical Sciences (Grant No. 2017-I2M-1-010); National Key Research and Development Program (Grant No. 2018YFC0311005); National Science and Technology Major Projects (Grant No. 2018ZX09711001-012). |
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Corresponding Authors:
Guanhua Du
E-mail: dugh@imm.ac.cn
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Issue Date: 23 October 2020
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1. L.H. Cazarolli, L. Zanatta, E.H. Alberton, M.S. Figueiredo, P. Folador, R.G. Damazio, M.G. Pizzolatti, F.R. Silva, Flavonoids:prospective drug candidates. Mini. Rev. Med. Chem. 8(13), 1429-1440 (2008)
2. A.N. Panche, A.D. Diwan, S.R. Chandra, Flavonoids:an overview. J. Nutr. Sci. 5, e47 (2016)
3. L. Gao, M. Zu, S. Wu, A.L. Liu, G.H. Du, 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Bioorg. Med. Chem. Lett. 21(19), 5964-5970 (2011)
4. G.B. Gonzales, In vitro bioavailability and cellular bioactivity studies of flavonoids and flavonoid-rich plant extracts:questions, considerations and future perspectives. Proc. Nutr. Soc. 76(3), 175-181 (2017)
5. S. Kumar, A.K. Pandey, Chemistry and biological activities of flavonoids:an overview. Sci. World J. 2013, 162750 (2013)
6. H. Zakaryan, E. Arabyan, A. Oo, K. Zandi, Flavonoids:promising natural compounds against viral infections. Adv. Virol. 162(9), 2539-2551 (2017)
7. S. Jo, S. Kim, D.H. Shin, M.S. Kim, Inhibition of SARS-CoV 3CL protease by flavonoids. J. Enzyme Inhib. Med. Chem. 35(1), 145-151 (2020)
8. Q. Zhao, Y. Zhang, G. Wang, L. Hill, J.K. Weng, X.Y. Chen, H. Xue, C. Martin, A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. Sci. Adv. 2(4), e1501780 (2016)
9. K. Kawabata, Y. Yoshioka, J. Terao, Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols. Molecules (Basel, Switzerland) 24(2), 370 (2019)
10. K. Murota, Y. Nakamura, M. Uehara, Flavonoid metabolism:the interaction of metabolites and gut microbiota. Biosci. Biotechnol. Biochem. 82(4), 600-610 (2018)
11. P.C. Hollman, M.N. Bijsman, Y. van Gameren, E.P. Cnossen, J.H. de Vries, M.B. Katan, The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radical Res. 31(6), 569-573 (1999)
12. H.S. Huang, C.G. Ma, Z.W. Chen, Advances in the research on pharmacological actions of flavone compounds. Zhongguo Zhong yao za zhi=Zhongguo zhongyao zazhi=China journal of Chinese materia medica 25(10), 589-592 (2000)
13. L.R. de Sousa, H. Wu, L. Nebo, J.B. Fernandes, M.F. da Silva, W. Kiefer, M. Kanitz, J. Bodem, W.E. Diederich, T. Schirmeister, P.C. Vieira, Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease:inhibition kinetics and docking studies. Bioorg. Med. Chem. 23(3), 466-470 (2015)
14. B. Ozcelik, M. Kartal, I. Orhan, Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm. Biol. 49(4), 396-402 (2011)
15. P. Sithisarn, M. Michaelis, M. Schubert-Zsilavecz, J. Cinatl Jr., Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virusinfected cells. Antiviral Res. 97(1), 41-48 (2013)
16. J.F. Shimizu, C.S. Lima, C.M. Pereira, C. Bittar, M.N. Batista, A.C. Nazare, C.R. Polaquini, C. Zothner, M. Harris, P. Rahal, L.O. Regasini, A.C.G. Jardim, Flavonoids from Pterogyne nitens inhibit hepatitis C virus entry. Sci. Rep. 7(1), 16127 (2017)
17. M.P. Nair, C. Kandaswami, S. Mahajan, K.C. Chadha, R. Chawda, H. Nair, N. Kumar, R.E. Nair, S.A. Schwartz, The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochem. Biophys. Acta. 1593(1), 29-36 (2002)
18. M.J. Bae, H.S. Shin, H.J. See, S.Y. Jung, D.A. Kwon, D.H. Shon, Baicalein induces CD4(+)Foxp3(+) T cells and enhances intestinal barrier function in a mouse model of food allergy. Sci. Rep. 6, 32225 (2016)
19. A.L. Liu, B. Liu, H.L. Qin, S.M. Lee, Y.T. Wang, G.H. Du, Anti-influenza virus activities of flavonoids from the medicinal plant Elsholtzia rugulosa. Planta Med. 74(8), 847-851 (2008)
20. M. Yonekawa, M. Shimizu, A. Kaneko, J. Matsumura, H. Takahashi, Suppression of R5-type of HIV-1 in CD4(+) NKT cells by Vdelta1(+) T cells activated by flavonoid glycosides, hesperidin and linarin. Sci. Rep. 9(1), 7506 (2019)
21. J.T. Ortega, M.L. Serrano, A.I. Suarez, J. Baptista, F.H. Pujol, L.V. Cavallaro, H.R. Campos, H.R. Rangel, Antiviral activity of flavonoids present in aerial parts of Marcetia taxifolia against hepatitis B virus, poliovirus, and herpes simplex virus in vitro. EXCLI J. 18, 1037-1048 (2019)
22. R.Y. Mekky, N. El-Ekiaby, S.A. El Sobky, N.M. Elemam, R.A. Youness, M. El-Sayed, M.T. Hamza, G. Esmat, A.I. Abdelaziz, Epigallocatechin gallate (EGCG) and miR-548m reduce HCV entry through repression of CD81 receptor in HCV cell models. Adv. Virol. 164(6), 1587-1595 (2019)
23. S. Nzuza, S. Zondi, P.M.O. Owira, Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo. PLoS ONE 12(11), e0183355 (2017)
24. A.K. Patra (ed.), Dietary phytochemicals and microbes (Springer, Dordrecht, 2012), pp. 93-126
25. T. Li, L. Liu, H. Wu, S. Chen, Q. Zhu, H. Gao, X. Yu, Y. Wang, W. Su, X. Yao, T. Peng, Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb. Antiviral Res. 144, 273-280 (2017)
26. C. Bus, N. Kusz, G. Jakab, S.A. Senobar Tahaei, I. Zupko, V. Endresz, A. Bogdanov, K. Burian, B. Csupor-Loffler, J. Hohmann, A. Vasas, Phenanthrenes from Juncus compressus Jacq. with promising antiproliferative and anti-HSV-2 activities. Molecules 23(8), 2085 (2018)
27. J. Dou, L. Chen, G. Xu, L. Zhang, H. Zhou, H. Wang, Z. Su, M. Ke, Q. Guo, C. Zhou, Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutininneuraminidase. Adv. Virol. 156(5), 793-801 (2011)
28. S. O'Neill, R.K. Porter, N. McNamee, V.G. Martinez, L. O'Driscoll, 2-Deoxy-D-glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype. Sci. Rep. 9(1), 3788 (2019)
29. M. Granato, M.S. Gilardini Montani, C. Zompetta, R. Santarelli, R. Gonnella, M.A. Romeo, G. D'Orazi, A. Faggioni, M. Cirone, Quercetin interrupts the positive feedback loop between STAT3 and IL-6, promotes autophagy, and reduces ROS, preventing EBV-driven B cell immortalization. Biomolecules 9(9), 482 (2019)
30. C. Zhang, N. Li, F. Niu, Baicalein triazole prevents respiratory tract infection by RSV through suppression of oxidative damage. Microb. Pathog. 131, 227-233 (2019)
31. S.M. Lipson, G. Karalis, L. Karthikeyan, F.S. Ozen, R.E. Gordon, S. Ponnala, J. Bao, W. Samarrai, E. Wolfe, Mechanism of anti-rotavirus synergistic activity by epigallocatechin gallate and a proanthocyanidin-containing nutraceutical. Food Environ. Virol. 9(4), 434-443 (2017)
32. H. Liu, F. Ye, Q. Sun, H. Liang, C. Li, R. Lu, B. Huang, W. Tan, L. Lai, Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. bioRxiv (2020). https://doi.org/10.1101/2020.04.10.035824
33. P. Mohammadi Pour, S. Fakhri, S. Asgary, M.H. Farzaei, J. Echeverria, The signaling pathways, and therapeutic targets of antiviral agents:focusing on the antiviral approaches and clinical perspectives of anthocyanins in the management of viral diseases. Front. Pharmacol. 10, 1207 (2019)
34. J. Adams, N. Patel, N. Mankaryous, M. Tadros, C.D. Miller, Nonnucleoside reverse transcriptase inhibitor resistance and the role of the second-generation agents. Ann. Pharmacother. 44(1), 157-165 (2010)
35. M. Aarthy, S.K. Singh, Discovery of potent inhibitors for the inhibition of dengue envelope protein:an in silico approach. Curr. Top. Med. Chem. 18(18), 1585-1602 (2018)
36. A. Prussia, P. Thepchatri, J.P. Snyder, R.K. Plemper, Systematic approaches towards the development of host-directed antiviral therapeutics. Int. J. Mol. Sci. 12(6), 4027-4052 (2011)
37. M.J. Hour, S.H. Huang, C.Y. Chang, Y.K. Lin, C.Y. Wang, Y.S. Chang, C.W. Lin, Baicalein, ethyl acetate, and chloroform extracts of Scutellaria baicalensis inhibit the neuraminidase activity of pandemic 2009 H1N1 and seasonal influenza A viruses. Evid. Based Complemen. Altern. Med. 2013, 750803 (2013)
38. A.L. Liu, H.D. Wang, S.M. Lee, Y.T. Wang, G.H. Du, Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorg. Med. Chem. 16(15), 7141-7147 (2008)
39. C. Li, J.S. Fang, W.W. Lian, X.C. Pang, A.L. Liu, G.H. Du, In vitro antiviral effects and 3D QSAR study of resveratrol derivatives as potent inhibitors of influenza H1N1 neuraminidase. Chem. Biol. Drug Des. 85(4), 427-438 (2015)
40. Y. Marunaka, Actions of quercetin, a flavonoid, on ion transporters:its physiological roles. Ann. N. Y. Acad. Sci. 1398(1), 142-151 (2017)
41. C.D.S. Mello, L.M.M. Valente, T. Wolff, R.S. Lima-Junior, L.G. Fialho, C.F. Marinho, E.L. Azeredo, L.M. Oliveira-Pinto, R.C.A. Pereira, A.C. Siani, C.F. Kubelka, Decrease in dengue virus-2 infection and reduction of cytokine/chemokine production by Uncaria guianensis in human hepatocyte cell line Huh-7. Mem. Inst. Oswaldo Cruz 112(6), 458-468 (2017)
42. R.S. Barboza, L.M.M. Valente, T. Wolff, I. Assuncao-Miranda, R.L.S. Neris, I.P. Guimaraes-Andrade, M. Gomes, Antiviral activity of Faramea hyacinthina and Faramea truncata leaves on dengue virus type-2 and their major compounds. Chem. Biodivers. 15(2), 1700393 (2018)
43. K. Zandi, B.T. Teoh, S.S. Sam, P.F. Wong, M.R. Mustafa, S. Abubakar, Antiviral activity of four types of bioflavonoid against dengue virus type-2. Virol. J. 8, 560 (2011)
44. P. Kumar, M. Khanna, V. Srivastava, Y.K. Tyagi, H.G. Raj, K. Ravi, Effect of quercetin supplementation on lung antioxidants after experimental influenza virus infection. Exp. Lung Res. 31(5), 449-459 (2005)
45. J. Johari, A. Kianmehr, M.R. Mustafa, S. Abubakar, K. Zandi, Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus. Int. J. Mol. Sci. 13(12), 16785-16795 (2012)
46. S. Ganesan, A.N. Faris, A.T. Comstock, Q. Wang, S. Nanua, M.B. Hershenson, U.S. Sajjan, Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral Res. 94(3), 258-271 (2012)
47. A.E. dos Santos, R.M. Kuster, K.A. Yamamoto, T.S. Salles, R. Campos, M.D. de Meneses, M.R. Soares, D. Ferreira, Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity. Parasites Vectors 7, 130 (2014)
48. W. Wu, R. Li, X. Li, J. He, S. Jiang, S. Liu, J. Yang, Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses 8(1), 6 (2015)
49. M. Lee, M. Son, E. Ryu, Y.S. Shin, J.G. Kim, B.W. Kang, H. Cho, H. Kang, Quercetin-induced apoptosis prevents EBV infection. Oncotarget 6(14), 12603-12624 (2015)
50. A. Rojas, J.A. Del Campo, S. Clement, M. Lemasson, M. GarciaValdecasas, A. Gil-Gomez, I. Ranchal, B. Bartosch, J.D. Bautista, A.R. Rosenberg, F. Negro, M. Romero-Gomez, Effect of quercetin on hepatitis C virus life cycle:from viral to host targets. Sci. Rep. 6, 31777 (2016)
51. Z. Liu, J. Zhao, W. Li, L. Shen, S. Huang, J. Tang, J. Duan, F. Fang, Y. Huang, H. Chang, Z. Chen, R. Zhang, Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine. Sci. Rep. 6, 19095 (2016)
52. G. Xu, J. Dou, L. Zhang, Q. Guo, C. Zhou, Inhibitory effects of baicalein on the influenza virus in vivo is determined by baicalin in the serum. Biol. Pharma. Bull. 33(2), 238-243 (2010)
53. E. Moghaddam, B.T. Teoh, S.S. Sam, R. Lani, P. Hassandarvish, Z. Chik, A. Yueh, S. Abubakar, K. Zandi, Baicalin, a metabolite of baicalein with antiviral activity against dengue virus. Sci. Rep. 4, 5452 (2014)
54. M.J. Wang, C.H. Yang, Y. Jin, C.B. Wan, W.H. Qian, F. Xing, X. Li, Y.Y. Liu, Baicalin inhibits coxsackievirus B3 replication by reducing cellular lipid synthesis. Am. J. Chin. Med. 48(1), 143-160 (2020)
55. M.R. Fesen, Y. Pommier, F. Leteurtre, S. Hiroguchi, J. Yung, K.W. Kohn, Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem. Pharmacol. 48(3), 595-608 (1994)
56. C.C. Wu, C.Y. Fang, Y.J. Cheng, H.Y. Hsu, S.P. Chou, S.Y. Huang, C.H. Tsai, J.Y. Chen, Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin. J. Biomed. Sci. 24(1), 2 (2017)
57. A. Hakobyan, E. Arabyan, A. Avetisyan, L. Abroyan, L. Hakobyan, H. Zakaryan, Apigenin inhibits African swine fever virus infection in vitro. Adv. Virol. 161(12), 3445-3453 (2016)
58. C. Shibata, M. Ohno, M. Otsuka, T. Kishikawa, K. Goto, R. Muroyama, N. Kato, T. Yoshikawa, A. Takata, K. Koike, The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. Virology 462-463, 42-48 (2014)
59. Y.B. Ryu, H.J. Jeong, J.H. Kim, Y.M. Kim, J.Y. Park, D. Kim, T.T. Nguyen, S.J. Park, J.S. Chang, K.H. Park, M.C. Rho, W.S. Lee, Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition. Bioorg. Med. Chem. 18(22), 7940-7947 (2010)
60. H.J. Choi, J.H. Kim, C.H. Lee, Y.J. Ahn, J.H. Song, S.H. Baek, D.H. Kwon, Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus. Antiviral Res. 81(1), 77-81 (2009)
61. S. Qian, W. Fan, P. Qian, D. Zhang, Y. Wei, H. Chen, X. Li, Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. Viruses 7(4), 1613-1626 (2015)
62. I. Kehinde, P. Ramharack, M. Nlooto, M. Gordon, The pharmacokinetic properties of HIV-1 protease inhibitors:a computational perspective on herbal phytochemicals. Heliyon 5(10), e02565 (2019)
63. C.-W. Chang, H.-C. Li, C.-F. Hsu, C.-Y. Chang, S.-Y. Lo, Increased ATP generation in the host cell is required for efficient vaccinia virus production. J. Biomed. Sci. 16(1), 80-80 (2009)
64. M.F. Visintini Jaime, F. Redko, L.V. Muschietti, R.H. Campos, V.S. Martino, L.V. Cavallaro, In vitro antiviral activity of plant extracts from Asteraceae medicinal plants. Virol. J. 10(1), 245 (2013)
65. M. Peng, S. Watanabe, K.W.K. Chan, Q. He, Y. Zhao, Z. Zhang, X. Lai, D. Luo, S.G. Vasudevan, G. Li, Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin. Antiviral Res. 143, 176-185 (2017)
66. C.C. Wu, C.Y. Fang, H.Y. Hsu, Y.J. Chen, S.P. Chou, S.Y. Huang, Y.J. Cheng, S.F. Lin, Y. Chang, C.H. Tsai, J.Y. Chen, Luteolin inhibits Epstein-Barr virus lytic reactivation by repressing the promoter activities of immediate-early genes. Antiviral Res. 132, 99-110 (2016)
67. W. Fan, S. Qian, P. Qian, X. Li, Antiviral activity of luteolin against Japanese encephalitis virus. Virus Res. 220, 112-116 (2016)
68. H. Yan, L. Ma, H. Wang, S. Wu, H. Huang, Z. Gu, J. Jiang, Y. Li, Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression. J. Nat. Med. 73(3), 487-496 (2019)
69. L. Bai, Y. Nong, Y. Shi, M. Liu, L. Yan, J. Shang, F. Huang, Y. Lin, H. Tang, Luteolin inhibits hepatitis B virus replication through extracellular signal-regulated kinase-mediated downregulation of hepatocyte nuclear factor 4alpha expression. Mol. Pharm. 13(2), 568-577 (2016)
70. R. Mehla, S. Bivalkar-Mehla, A. Chauhan, A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. PLoS ONE 6(11), e27915 (2011)
71. L. Yi, Z. Li, K. Yuan, X. Qu, J. Chen, G. Wang, H. Zhang, H. Luo, L. Zhu, P. Jiang, L. Chen, Y. Shen, M. Luo, G. Zuo, J. Hu, D. Duan, Y. Nie, X. Shi, W. Wang, Y. Han, T. Li, Y. Liu, M. Ding, H. Deng, X. Xu, Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J. Virol. 78(20), 11334-11339 (2004)
72. T.C. Theoharides, COVID-19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin, BioFactors (England, Oxford, 2020)
73. W. Dai, J. Bi, F. Li, S. Wang, X. Huang, X. Meng, B. Sun, D. Wang, W. Kong, C. Jiang, W. Su, Antiviral efficacy of flavonoids against enterovirus 71 infection in vitro and in newborn mice. Viruses 11(7), 625 (2019)
74. G. Enkhtaivan, K.M. Maria John, M. Pandurangan, J.H. Hur, A.S. Leutou, D.H. Kim, Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts. Saudi J. Biol. Sci. 24(7), 1646-1656 (2017)
75. M. Sochocka, M. Sobczynski, M. Ochnik, K. Zwolinska, J. Leszek, Hampering herpesviruses HHV-1 and HHV-2 infection by extract of Ginkgo biloba (EGb) and its phytochemical constituents. Front. Microbiol. 10, 2367 (2019)
76. S. Bhargava, T. Patel, R. Gaikwad, U.K. Patil, S. Gayen, Identification of structural requirements and prediction of inhibitory activity of natural flavonoids against Zika virus through molecular docking and Monte Carlo based QSAR simulation. Nat. Prod. Res. 33(6), 851-857 (2019)
77. K. Qian, A.J. Gao, M.Y. Zhu, H.X. Shao, W.J. Jin, J.Q. Ye, A.J. Qin, Genistein inhibits the replication of avian leucosis virus subgroup J in DF-1 cells. Virus Res. 192, 114-120 (2014)
78. B.N. Smith, A. Morris, M.L. Oelschlager, J. Connor, R.N. Dilger, Effects of dietary soy isoflavones and soy protein source on response of weanling pigs to porcine reproductive and respiratory syndrome viral infection. J. Anim. Sci. 97(7), 2989-3006 (2019)
79. E. Arabyan, A. Hakobyan, A. Kotsinyan, Z. Karalyan, V. Arakelov, G. Arakelov, K. Nazaryan, A. Simonyan, R. Aroutiounian, F. Ferreira, H. Zakaryan, Genistein inhibits African swine fever virus replication in vitro by disrupting viral DNA synthesis. Antiviral Res. 156, 128-137 (2018)
80. H. Huang, D. Liao, L. Liang, L. Song, W. Zhao, Genistein inhibits rotavirus replication and upregulates AQP4 expression in rotavirus-infected Caco-2 cells. Adv. Virol. 160(6), 1421-1433 (2015)
81. D.F. Argenta, I.T. Silva, V.L. Bassani, L.S. Koester, H.F. Teixeira, C.M. Simoes, Antiherpes evaluation of soybean isoflavonoids. Adv. Virol. 160(9), 2335-2342 (2015)
82. K.M. Bedard, M.L. Wang, S.C. Proll, Y.M. Loo, M.G. Katze, M. Gale Jr., S.P. Iadonato, Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses. J. Virol. 86(13), 7334-7344 (2012)
83. M. Nukui, C.M. O'Connor, E.A. Murphy, The natural flavonoid compound deguelin inhibits HCMV lytic replication within fibroblasts. Viruses 10(11), 614 (2018)
84. S. Mediouni, J.A. Jablonski, S. Tsuda, A. Richard, C. Kessing, M.V. Andrade, A. Biswas, Y. Even, T. Tellinghuisen, H. Choe, M. Cameron, M. Stevenson, S.T. Valente, Potent suppression of HIV-1 cell attachment by Kudzu root extract. Retrovirology 15(1), 64 (2018)
85. L. Zhong, J. Hu, W. Shu, B. Gao, S. Xiong, Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication. Cell Death Dis. 6(5), e1770 (2015)
86. C.E. Isaacs, G.Y. Wen, W. Xu, J.H. Jia, L. Rohan, C. Corbo, V. Di Maggio, E.C. Jenkins Jr., S. Hillier, Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus. Antimicrob. Agents Chemother. 52(3), 962-970 (2008)
87. C.C. Colpitts, L.M. Schang, A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans. J. Virol. 88(14), 7806-7817 (2014)
88. J.M. Weber, A. Ruzindana-Umunyana, L. Imbeault, S. Sircar, Inhibition of adenovirus infection and adenain by green tea catechins. Antiviral Res. 58(2), 167-173 (2003)
89. S. Liu, H. Li, L. Chen, L. Yang, L. Li, Y. Tao, W. Li, Z. Li, H. Liu, M. Tang, A.M. Bode, Z. Dong, Y. Cao, (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBVpositive cells. Carcinogenesis 34(3), 627-637 (2013)
90. S. Liu, H. Li, L. Chen, L. Yang, L. Li, Y. Tao, W. Li, Z. Li, H. Liu, M. Tang, A.M. Bode, Z. Dong, Y. Cao, (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBVpositive cells. Carcinogenesis 34(3), 627-637 (2012)
91. K. Yamaguchi, M. Honda, H. Ikigai, Y. Hara, T. Shimamura, Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). Antiviral Res. 53(1), 19-34 (2002)
92. P. Hartjen, S. Frerk, I. Hauber, V. Matzat, A. Thomssen, B. Holstermann, H. Hohenberg, W. Schulze, J. Schulze Zur Wiesch, J. van Lunzen, Assessment of the range of the HIV-1 infectivity enhancing effect of individual human semen specimen and the range of inhibition by EGCG. AIDS Res. Ther. 9(1), 2 (2012)
93. E. Rrapo, Y. Zhu, J. Tian, H. Hou, A. Smith, F. Fernandez, J. Tan, B. Giunta, Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice. Am. J. Transl. Res. 1(1), 72-79 (2009)
94. C. Chen, H. Qiu, J. Gong, Q. Liu, H. Xiao, X.W. Chen, B.L. Sun, R.G. Yang, (-)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus. Adv. Virol. 157(7), 1301-1312 (2012)
95. M.W. Roomi, R.J. Jariwalla, T. Kalinovsky, N. Roomi, A. Niedzwiecki, M. Rath, Inhibition of cellular invasive parameters in influenza A virus-infected MDCK and Vero cells by a nutrient mixture. BioFactors (Oxford, England) 33(1), 61-75 (2008)
96. Z.F. Yang, L.P. Bai, W.B. Huang, X.Z. Li, S.S. Zhao, N.S. Zhong, Z.H. Jiang, Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure-activity relationship analysis. Fitoterapia 93, 47-53 (2014)
97. B.M. Carneiro, M.N. Batista, A.C.S. Braga, M.L. Nogueira, P. Rahal, The green tea molecule EGCG inhibits Zika virus entry. Virology 496, 215-218 (2016)
98. S. Harakeh, M. Diab-Assaf, R. Azar, H.M. Hassan, S. Tayeb, K. Abou-El-Ardat, G.A. Damanhouri, I. Qadri, A. Abuzenadah, A. Chaudhary, T. Kumosani, A. Niedzwiecki, M. Rath, H. Yacoub, E. Azhar, E. Barbour, Epigallocatechin-3-gallate inhibits taxdependent activation of nuclear factor kappa B and of matrix metalloproteinase 9 in human T-cell lymphotropic virus-1 positive leukemia cells. Asian Pac. J. Cancer Prev. 15(3), 1219-1225 (2014)
99. H.Y. Ho, M.L. Cheng, S.F. Weng, Y.L. Leu, D.T. Chiu, Antiviral effect of epigallocatechin gallate on enterovirus 71. J. Agric. Food Chem. 57(14), 6140-6147 (2009)
100. S.P. Reid, A.C. Shurtleff, J.A. Costantino, S.R. Tritsch, C. Retterer, K.B. Spurgers, S. Bavari, HSPA5 is an essential host factor for Ebola virus infection. Antiviral Res. 109, 171-174 (2014) |
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