Two New C21 Steroidal Glycosides from the Roots of <i>Cynanchum paniculatum</i>

doi:10.1007/s13659-019-0205-2

Natural Products and Bioprospecting

2019, Vol. 9

Issue (3) : 209-214 DOI: 10.1007/s13659-019-0205-2

ORIGINAL ARTICLES

Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

Hai-Li Yu^1,2, Qin Long^1,2, Wen-Fang Yi^1,2, Bao-Jia Yang^1,2, Yu Song^1,2, Xiao Ding¹, Shun-Lin Li¹, Xiao-Jiang Hao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

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Abstract Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability.

Keywords Cynanchum paniculatum Steroidal glycosides Bioactivities NMR data

Fund:This project was supported financially by grants from the National Natural Science Foundation of China (Nos. 31770389, 81703393).

Corresponding Authors: Xiao Ding, Shun-Lin Li E-mail: dingxiao@mail.kib.ac.cn;lisl@mail.kib.ac.cn

Issue Date: 05 June 2019

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	Xiao-Jiang Hao

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Hai-Li Yu,Qin Long,Wen-Fang Yi, et al. Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum[J]. Natural Products and Bioprospecting, 2019, 9(3): 209-214.

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http://npb.kib.ac.cn/EN/10.1007/s13659-019-0205-2 OR http://npb.kib.ac.cn/EN/Y2019/V9/I3/209

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