Natural Products and Bioprospecting    2018, Vol. 8 Issue (4) : 245-263     DOI: 10.1007/s13659-018-0176-8
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Research of Panax spp. in Kunming Institute of Botany, CAS
Yi-Jun Qiao1,2, Jia-Huan Shang1,2, Dong Wang1, Hong-Tao Zhu1, Chong-Ren Yang1, Ying-Jun Zhang1,3
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China
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Abstract  Panax, a genus of the Araliaceae family, is an important herbal group in traditional Chinese medicine (TCM). Nine species and three varieties are included in the genus of Panax, in which nearly all species have been used for medicinal purposes. Among them, Panax notoginseng (Burk) F. H. Chen, Panax ginseng C. A. Meyer and Panax quinquefolius L. are the most representative and valuable herbs world-wide, with a long history of cultivation. As the main bioactive chemical constituents, saponins with different aglycones are the major components in various Panax spp., and their pharmacological activities are mainly reflected in the effects on blood system, cardio-and cerebro-vascular systems, nervous system, metabolism, and immune regulation. Researchers of Kunming Institute of Botany (KIB), Chinese Academy of Sciences (CAS), have put many efforts into conducting the investigations on Panax species. Herein, we reviewed the research progress on Panax spp. in KIB, CAS, over the past few decades, from the aspects of history and origin, phytochemistry and pharmacological activities.
Keywords Panax spp.      Phytochemistry      Pharmacological activities      Saponins     
Fund:This work was supported by the Major Science and Technique Programs in Yunnan Province (2016ZF001-001), and the Science and Technology Planning Project of Yunnan Province (2013FC008).
Corresponding Authors: Ying-Jun Zhang,zhangyj@mail.kib.ac.cn     E-mail: zhangyj@mail.kib.ac.cn
Issue Date: 28 August 2018
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Yi-Jun Qiao,Jia-Huan Shang,Dong Wang, et al. Research of Panax spp. in Kunming Institute of Botany, CAS[J]. Natural Products and Bioprospecting, 2018, 8(4): 245-263.
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http://npb.kib.ac.cn/EN/10.1007/s13659-018-0176-8     OR     http://npb.kib.ac.cn/EN/Y2018/V8/I4/245
1. F.O.C. Board, Flora of China, Panax (Science Press, Beijing, 2004), pp. 59-74
2. Editorial Board of Chinese Pharmacopoeia, Chinese Pharmacopoeia, vol. 1 (Chemistry and Industry Press, Beijing, 2015), pp. 8-9, 11-12, 131-132, 138-139, 271-272
3. J. Zhou, W.G. Huang, M.Z. Wu, C.R. Yang, G.M. Feng, Z.Y. Wu, J. Syst. Evol. 13, 29-45 (1975)
4. I. Mucalo, E. Jovanovski, D. Rahelic, V. Bozikov, Z. Romic, V. Vuksan, J. Ethnopharmacol. 150, 148-153 (2013)
5. Y. Wang, Y.H. Chen, H. Xu, H.M. Luo, R.Z. Jiang, J. Ethnopharmacol. 148, 946-950 (2013)
6. Chinese medicinal materials company, Chinese Medicinal Herbs in Common Use (Science Press, Beijing, 1995), pp. 17-27
7. C.R. Yang, Chin. Med. J. Res. Prac. 29, 83-86 (2015)
8. B.X. Liu, S.J. Pei, G.P. Dong, B.Y. Liu, J.R. Wei, R. Yue, C.L. Long, Chin. Med. Culture 2, 44-49 (2017)
9. M.Z. Wu, Acta Bot. Yunnan. 1, 119-124 (1979)
10. J. Zhou, M.Z. Wu, S. Taniyasu, H. Besso, O. Tanaka, Y. Saruwatari, T. Fuwa, Chem. Pharm. Bull. 29, 2844-2850 (1981)
11. H. Matsuura, R. Kasai, O. Tanaka, Y.I. Saruwatari, T. Fuwa, J. Zhou, Chem. Pharm. Bull. 31, 2281-2287 (1983)
12. J. Zhou, G.Y. Wang, M.Z. Wu, J. Zhou, Chin. Pharm. J. 20, 337-338 (1985)
13. P. Zhao, Y.Q. Liu, C.R. Yang, Phytochemistry 41, 1419-1422 (1996)
14. J.P. Song, J. Zeng, X.M. Cui, Y. Dai, Z.Y. Jiang, X.M. Zhang, J.M. Zhou, Y.B. Ma, J.J. Chen, J. Yunnan Univ. 29, 287-290 (2007)
15. J. Zeng, X.M. Cui, J.M. Zhou, Z.Y. Jiang, X.M. Zhang, J.J. Chen, J. Chin. Med. Mater. 30, 1388-1391 (2007)
16. X.M. Cui, Z.Y. Jiang, J. Zeng, J.M. Zhou, J.J. Chen, X.M. Zhang, L.S. Xu, Q. Wang, J. Asian Nat. Prod. Res. 10, 845-849 (2008)
17. P. Zhao, Y.Q. Liu, C.R. Yang, Acta Bot. Yunnan. 15, 409-412 (1993)
18. S.M. Wang, N.H. Tan, Y.B. Yang, M. He, Nat. Prod. Res. Dev. 16, 383-386 (2004)
19. H.Z. Li, R.W. Teng, C.R. Yang, Chin. Chem. Lett. 12, 59-62 (2001)
20. S. Taniyasu, O. Tanaka, T.R. Yang, J. Zhou, Planta Med. 44, 124-125 (1982)
21. C.R. Yang, R. Kasai, J. Zhou, O. Tanaka, Phytochemistry 22, 1473-1478 (1983)
22. H.Z. Li, Y.J. Zhang, C.R. Yang, Nat. Prod. Res. Dev. 18, 549-554 (2006)
23. X.Y. Wang, D. Wang, X.X. Ma, Y.J. Zhang, C.R. Yang, Helv. Chim. Acta 91, 60-66 (2008)
24. J.P. Song, X.M. Cui, J. Zeng, J.J. Chen, X.M. Mei, Y.B. Ma, Li Shizhen Med. Mater. Med. Res. 21, 565-567 (2010)
25. L.G. Zhou, G.Z. Zheng, F.Y. Gan, S.L. Wang, C.R. Yang, C. Xu, Acta Pharm. Sin. 26, 876-880 (1991)
26. R.W. Teng, H.Z. Li, D.Z. Wang, C.R. Yang, Helv. Chim. Acta 87, 1270-1278 (2004)
27. J.T. Chen, H.Z. Li, D. Wang, Y.J. Zhang, C.R. Yang, Helv. Chim. Acta 89, 1442-1448 (2010)
28. C.R. Yang, F.Y. Ni, J. Zhou, Acta Bot. Yunnan. 8, 87-92 (1986)
29. J.X. Wei, L.Y. Chang, J.F. Wang, F. Edmund, J. Monika, P. Heinrich, B. Eberhard, Planta Med. 45, 167-171 (1982)
30. R.W. Teng, H.Z. Li, X.M. Zhang, X.K. Liu, D.Z. Wang, C.R. Yang, Chin. Chem. Lett. 12, 239-242 (2001)
31. R.W. Teng, H.Z. Li, J.T. Chen, D.Z. Wang, Y.N. He, C.R. Yang, Magn. Reson. Chem. 40, 483-488 (2002)
32. C.R. Yang, Z.H. Cui, M.Z. Wu, J. Zhou, Tradit. Chin. Med. J. 10(33-34), 23 (1985)
33. P.Y. Liao, D. Wang, Y.J. Zhang, C.R. Yang, J. Agric. Food Chem. 56, 1751 (2008)
34. Q. Liu, J.J. Lv, M. Xu, D. Wang, H.T. Zhu, C.R. Yang, Y.J. Zhang, Nat. Prod. Bioprospect. 1, 124-128 (2011)
35. C.Z. Gu, J.J. Lv, X.X. Zhang, Y.J. Qiao, H. Yan, Y. Li, D. Wang, H.T. Zhu, H.R. Luo, C.R. Yang, M. Xu, Y.J. Zhang, J. Nat. Prod. 78, 1829-1840 (2015)
36. C.Z. Gu, J.J. Lv, X.X. Zhang, H. Yan, H.T. Zhu, H.R. Luo, D. Wang, C.R. Yang, M. Xu, Y.J. Zhang, Fitoterapia 103, 97-105 (2015)
37. C.Z. Gu, Y.J. Qiao, D. Wang, H.T. Zhu, C.R. Yang, M. Xu, Y.J. Zhang, Nat. Prod. Res. 32, 294-301 (2018)
38. D. Wang, P.Y. Liao, H.T. Zhu, K.K. Chen, M. Xu, Y.J. Zhang, C.R. Yang, Food Chem. 132, 1808-1813 (2012)
39. G.H. Li, Y.M. Shen, K.Q. Zhang, Chin. Chem. Lett. 16, 359-361 (2005)
40. G.H. Li, Y.M. Shen, Q.F. Wang, K.Q. Zhang, Chin. Tradit. Herb. Drugs 36, 499-500 (2005)
41. D. Wang, H.Z. Li, K.K. Chen, Y.J. Zhang, Acta Bot. Yunnan. 27, 685-690 (2005)
42. D. Wang, H.L. Koh, Y. Hong, H.T. Zhu, M. Xu, Y.J. Zhang, C.R. Yang, Phytochemistry 93, 88-95 (2013)
43. D. Wang, D. Hong, H.L. Koh, Y.J. Zhang, C.R. Yang, Y. Hong, Acta Pharmacol. Sin. 29, 1137-1140 (2008)
44. D. Wang, H.T. Zhu, K.K. Chen, M. Xu, Y.J. Zhang, C.R. Yang, Chin. Med. 6, 1-4 (2011)
45. L.G. Zhou, G.Z. Zheng, S.L. Wang, F.Y. Gan, Cell Res. 2, 83-87 (1992)
46. R.W. Teng, H.Z. Li, D.Z. Wang, Y.N. He, C.R. Yang, Chin. J. Magn. Reson. 17, 461-468 (2000)
47. R.W. Teng, H.Z. Li, D.Z. Wang, Y.N. He, C.R. Yang, Chin. J. Magn. Reson. 19, 25-32 (2002)
48. D.Y.Q. Hong, A.J. Lau, C.L. Yeo, X.K. Liu, C.R. Yang, H.L. Koh, Y. Hong, J. Agric. Food Chem. 53, 8460-8467 (2005)
49. Z.Q. Shen, L.O. Wu, W.Y. Lei, Z.H. Chen, J.K. Liu, Chin. Tradit. Herb. Drugs 33, 138-140 (2002)
50. L.C. Song, J. Liu, Y. Zhang, Q.Z. Zan, M.Z. Wu, J. Zhou, Chin. Pharm. Bull. 17, 3-5 (1982)
51. D. Song, X. Wei, Y.Y. Yuan, Y.L. Zhao, Y. Zhang, J.H. Shang, Chin. J. Info. TCM 24, 129-132 (2017)
52. J.J. Liu, Y.T. Wang, L. Qiu, Y.Y. Yu, C.M. Wang, Expert Opin. Invest. Drugs 23, 523-539 (2014)
53. Q.B. Fan, X.W. Li, L.G. Jian, B.Y. Qin, J. Zhengzhou Univ. 49, 48-52 (2014)
54. Y.Y. Zang, W.H. Li, X.J. Guo, L.Q. Wan, F.H. Li, S. Zhang, J.B. Ma, Z.Y. Jiang, Y.H. Hu, F. Zhang, J. Yunnan Univ. Tradit. Chin. Med. 39, 1-4 (2016)
55. D.S. Kim, Y.J. Chang, U. Zedk, P. Zhao, Y.Q. Liu, C.R. Yang, Phytochemistry 40, 1493-1497 (1995)
56. C.R. Yang, R.C. Yao, D.C. Ruan, Z.L. Chen, Acta Bot. Yunnan. 11, 276-284 (1989)
57. S.U. Jian, H.Z. Li, C.R. Yang, China J. Chin. Mater. Med. 28, 830-833 (2003)
58. J. Su, H.Z. Li, L.Y. Kong, C.R. Yang, Nat. Prod. Res. Dev. 16, 561-564 (2004)
59. T. Morita, R. Kasai, H. Kohda, O. Tanaka, J. Zhou, C.R. Yang, Chem. Pharm. Bull. 31, 3205-3209 (1983)
60. M. Zhou, M. Xu, D. Wang, H.T. Zhu, C.R. Yang, Y.J. Zhang, Helv. Chim. Acta 94, 2010-2019 (2011)
61. T. Morita, R. Kasai, O. Tanaka, J. Zhou, T.R. Yang, J. Shoji, Chem. Pharm. Bull. 30, 4341-4346 (1982)
62. C.R. Yang, M.Z. Wu, J. Zhou, Acta Bot. Yunnan. 6, 118-120 (1984)
63. D.Q. Wang, J. Fan, X.B. Wang, B.S. Feng, Acta Bot. Sin. 30, 403-408 (1988)
64. B.S. Feng, X.B. Wang, D.Q. Wang, Acta Bot. Yunnan. 9, 477-484 (1987)
65. D.Q. Wang, B.S. Feng, X.B. Wang, C.R. Yang, J. Zhou, Acta Pharm. Sin. 24, 633-636 (1989)
66. C.R. Yang, Z.D. Jiang, M.Z. Wu, J. Zhou, Z.Z. Tian, Acta Pharm. Sin. 19, 232-236 (1984)
67. Z. Wang, Z.J. Jia, Z.Q. Zhu, Acta Bot. Sin. 27, 618-624 (1985)
68. C.R. Yang, Z.D. Jiang, J. Zhou, J.L.C. Li, Z.Z. Tian, Acta Bot. Yunnan. 7, 103-108 (1985)
69. D.Q. Wang, J. Fang, S. Li, X.B. Wang, B.S. Feng, C.R. Yang, J. Zhou, Y.C. Ning, Y.P. Feng, J.X. Yao, Acta Bot. Yunnan. 10, 101-104 (1988)
70. D.Q. Wang, J. Fan, B.S. Feng, S.R. Li, X.B. Wang, C.R. Yang, J. Zhou, Acta Pharm. Sin. 24, 593-599 (1989)
71. T. Wang, R. Guo, G. Zhou, X. Zhou, Z. Kou, F. Sui, C. Li, L. Tang, Z. Wang, J. Ethnopharmacol. 188, 234-258 (2016)
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