Steroidal Saponins from the Genus <i>Smilax</i> and Their Biological Activities

doi:10.1007/s13659-017-0139-5

Natural Products and Bioprospecting

2017, Vol. 7

Issue (4) : 283-298 DOI: 10.1007/s13659-017-0139-5

Review

Steroidal Saponins from the Genus Smilax and Their Biological Activities

Li-Wen Tian¹, Zhen Zhang¹, Hai-Lan Long¹, Ying-Jun Zhang²

1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

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Abstract The Smilax species, widely distributed in tropical region of the world and the warm areas of East Asia and North America, are extensively used as folk medicine to treat inflammatory disorders. Chemical investigation on Smilax species showed they are rich sources of steroidal saponins with diversified structure types, including spirostane, isospirostane, furostane, pregnane, and cholestane. This review mainly summarizes the steroidal saponins (1-104) reported from the genus Smilax between 1967 and 2016, and their biological activities. The relationship between structures of steroidal saponins and related biological activities were briefly discussed.

Keywords Smilax Steroidal saponins Biological activities

Fund:This work was financially supported by the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (No. P2015-KF07), Science and Technology Program of Guangzhou, China (No. 201607010147), and Guangdong Medical Science Foundation (No. A2015225).

Issue Date: 07 February 2018

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Li-Wen Tian,Zhen Zhang,Hai-Lan Long, et al. Steroidal Saponins from the Genus Smilax and Their Biological Activities[J]. Natural Products and Bioprospecting, 2017, 7(4): 283-298.

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http://npb.kib.ac.cn/EN/10.1007/s13659-017-0139-5 OR http://npb.kib.ac.cn/EN/Y2017/V7/I4/283

1. Editorial Committee of the flora of the Chinese Aacdemy of Sciences, ‘Flora Reipublicae Popularis Sinicae’, Beijing House of Science Press (1978)
2. Chinese Pharmacopoeia Commission, Chinese Pharmacopoeia (China Medical Science Press, Beijing, 2015)
3. Compilation Group of Chinese Hebral Medicine, The Assembly of Chinese Herbal Medicine (People's Medical Publishing House, Beijing, 1975)
4. H. Ma, W. Wang, F. Dong, Zhongguo Yaofang 20, 1191-1193 (2009)
5. Y. Yi, Y. Liu, Y. Peng, Y. Xie, S. Wang, Zhongguo Yaofang 25, 1430-1432 (2011)
6. J. Guo, F. Qian, J. Li, Q. Xu, T. Chen, Clin. Chem. 53, 465-471 (2007)
7. R.R. Bernardo, A.V. Pinto, J.P. Parente, Phytochemistry 43, 465-469 (1996)
8. Y. Sashida, S. Kubo, Y. Mimaki, T. Nikaido, T. Ohmoto, Phytochemistry 31, 2439-2443 (1992)
9. K.Y. Cho, Yakhak Hoechi 39, 141-147 (1995)
10. Z. Belhouchet, M. Sautour, T. Miyamoto, M.A. Lacaille-Dubois, Chem. Pharm. Bull. 56, 1324-1327 (2008)
11. V.L. Challinor, P.G. Parsons, S. Chap, E.F. White, J.T. Blanchfield, R.P. Lehmann, J.J. De Voss, Steroids 77, 504-511 (2012)
12. G.B. Iskenderov, M.N. Mamedova, N.I. Musaev, Chem. Nat. Comp. 11, 820 (1975)
13. Y. Ju, Z.J. Jia, Phytochemistry 31, 1349-1351 (1992)
14. Y. Ju, Z.J. Jia, Phytochemistry 33, 1193-1195 (1993)
15. Y. Ju, H.R. Peng, Z.J. Jia, X.J. Sun, J. Lanzhou Univ. (Nat. Sci.) 30, 64-67 (1994)
16. X.J. Sun, Y. Ju, M. Du, Z.J. Jia, Zhongcaoyao 26, 395-396 (1995)
17. A. Ivanova, B. Mikhova, I. Klaiber, D. Dinchev, I. Kostova, Nat. Prod. Res. 23, 916-924 (2009)
18. T. Lin, H.L. Huang, R.H. Liu, J.C. Shu, G. Ren, F. Shao, L.S. Liu, Magn. Reson. Chem. 50, 813-817 (2012)
19. J. Xu, X. Li, C.C. Zhao, Y. Wang, Nat. Prod. Res. 22, 884-889 (2008)
20. X.H. Wu, C.Z. Wang, S.Q. Wang, C. Mi, Y. He, J. Zhang, Y.W. Zhang, S. Anderson, C.S. Yuan, J. Ethnopharmacol. 162, 362-368 (2015)
21. C. Zhang, S. Feng, L. Zhang, Z. Ren, Nat. Prod. Res. 27, 1255-1260 (2013)
22. I.Khan,M.Nisar,F.Ebad,S.Nadeem,M.Saeed,H.Khan,F.Samiullah, N.Karim Khuda, Z. Ahamd, J. Ethnopharmacol. 121, 175-177 (2009)
23. S. Kubo, Y. Mimaki, Y. Sashida, T. Nikaido, T. Ohmoto, Phytochemistry 31, 2445-2450 (1992)
24. P.Y. Hou, C. Mi, Y. He, J. Zhang, S.Q. Wang, F. Yu, S. Anderson, Y.W. Zhang, X.H. Wu, Fitoterapia 105, 43-48 (2015)
25. M. Sautour, T. Miyamoto, M.A. Lacaille-Dubois, J. Nat. Prod. 68, 1489-1493 (2005)
26. M. Sautour, T. Miyamoto, M.A. Lacaille-Dubois, Planta Med. 72, 667-670 (2006)
27. H.L. Huang, R.H. Liu, F. Shao, Magn. Reson. Chem. 47, 741-745 (2009)
28. J. Xu, S. Feng, Q. Wang, Y. Cao, M. Sun, C. Zhang, Molecules 19, 20975-20987 (2014)
29. B.P. da Silva, J.P. Parente, Z. Naturforsch. B 63, 95-100 (2008)
30. B. Shao, H. Guo, Y. Cui, M. Ye, J. Han, D. Guo, Phytochemistry 68, 623-630 (2007)
31. A. Ivanova, B. Mikhova, T. Batsalova, B. Dzhambazov, I. Kostova, Fitoterapia 82, 282-287 (2011)
32. F. Liang, J.W. He, G.H. Zhu, R.H. Liu, J.C. Shu, F. Shao, H.L. Huang, Phytochem. Lett. 16, 294-298 (2016)
33. Y. Ju, Z. Jia, X. Sun, Phytochemistry 37, 1433-1436 (1994)
34. V.L. Challinor, J.J. De Voss, Nat. Prod. Rep. 30, 429-454 (2013)
35. C.R. Yang, Y. Zhang, M.R. Jacob, S.I. Khan, Y.J. Zhang, X.C. Li, Antimicrb. Agents. Chemother. 50, 1710-1714 (2006)
36. X.S. Shu, Z.H. Gao, X.L. Yang, J. Ethnopharmacol. 103, 327-332 (2006)
37. W.S. Laitonjam, B.D. Kongbrailatpam, Nat. Prod. Res. 24, 1168-1176 (2010)
38. R. Tschesche, G. Lüdke, G. Wulff, Tetrahedron Lett. 8, 2785-2790 (1967)
39. Y. Ju, Z.J. Jia, H.R. Peng, X.J. Sun, Chin. Chem. Lett. 4, 137-138 (1993)
40. Y. Ju, Z.J. Jia, Chem. J. Chin. Univ. 11, 1386-1387 (1990)
41. Z.H. Jia, Y. Ju, M. Du, Chin. Chem. Lett. 3, 431-432 (1992)
42. Y. Ju, Z.J. Jia, Y.N. Wu, Chin. Chem. Lett. 2, 853-854 (1991)
43. C.L. Zhang, W. Zhu, Y.M. Cheng, W.C. Li, Xibei Zhiwu Xuebao 23, 1973-1976 (2003)
44. C.L. Zhang, J.M. Gao, W. Zhu, Phytochem. Lett. 5, 49-52 (2012)
45. M.H. Woo, J.C. Do, K.H. Son, J. Nat. Prod. 55, 1129-1135 (1992)
46. C.L. Zhang, W. Zhu, X.M. Li, B.F. Su, X.Y. Yan, Linye Kexue 42, 69-73 (2006)
47. Z.H. Jia, Y. Ju, Phytochemistry 31, 3173-3175 (1992)
48. C.L. Zhang, W.C. Li, J.M. Gao, J.X. Fu, J. Northwest Sci-Tech Univ. of Agric. For. (Nat. Sci.) 31, 163-166 (2003)
49. Y. Ju, Z.J. Jia, Chem. J. Chin. Univ. 12, 1488-1489 (1991)
50. C. Lavaud, Planta Med. Phytother. 26, 64-73 (1993)
51. J.Y. Liu, J.X. Fu, J.M. Gao, M.H. Qiu, J. Northwest Sci-Tech Univ. of Agric. For. (Nat. Sci.) 30, 222-224 (2002)
52. W. Chen, X.A. Shou, Y. Chen, N. Qin, W. Qiao, S.A. Tang, H.Q. Duan, Chem. Nat. Comp. 50, 989-993 (2014)
53. J. Li, X. Bi, G. Zheng, Y. Hitoshi, T. Ikeda, T. Nohara, Chem. Pharm. Bull. 54, 1451-1454 (2006)
54. X.H. Wu, C.Z. Wang, J. Zhang, S.Q. Wang, L. Han, Y.W. Zhang, C.S. Yuan, Phytother. Res. 28, 1822-1828 (2014)
55. X.H. Wu, J. Zhang, S.Q. Wang, V.C. Yang, S. Anderson, Y.W. Zhang, Phytomedicine 21, 1196-1201 (2014)

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