Identification and Bioactivities of Secondary Metabolites Derived from Endophytic Fungi Isolated from Ethnomedicinal Plants of Tujia in Hubei Province: A Review

doi:10.1007/s13659-020-00295-5

Natural Products and Bioprospecting

2021, Vol. 11

Issue (2) : 185-205 DOI: 10.1007/s13659-020-00295-5

REVIEWS

Identification and Bioactivities of Secondary Metabolites Derived from Endophytic Fungi Isolated from Ethnomedicinal Plants of Tujia in Hubei Province: A Review

Ke Ye, Hong-Lian Ai, Ji-Kai Liu

School of Pharmaceutical Science, South-Central University for Nationalities, Wuhan 430074, Hubei, China

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Abstract Tujia is a national minority, inhabiting in the mountainous Wuling area in China. Since 1978, Tujia medicine has been studied, summarized and developed, leading to numerous achievements by Chinese researchers, such as the publishing of approximately 30 monographs of Tujia medicine. These publications are focused on summarizing and improving the theory of Tujia medicine and developing clinical therapies from this system of medicine. The shortage of natural medicinal plants used in Tujia medicine has created the need to discover new resources to replace them and protect endangered natural plant species. Endophytic fungi are one of the conservation options, are considered a source of new bioactive natural products, and are a renewable and inexhaustible source of new drugs and agrochemicals. This review summarizes 260 compounds from endophytic fungi that have been previously isolated from the medicinal plants of Tujia. These compounds include steroids, terpenoids, meroterpenoids, polyketides, alkaloids, peptides, aliphatic compounds, aromatic compounds, and heterocyclic compounds.

Keywords Tujia medicine Endophytic fungi Secondary metabolites Bioactivities

Fund:This work was financially supported by the National Natural Science Foundation of China (Grants No.32000011 and 21961142008).

Corresponding Authors: Hong-Lian Ai E-mail: aihonglian@mail.scuec.edu.cn

Issue Date: 07 April 2021

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Ke Ye,Hong-Lian Ai,Ji-Kai Liu. Identification and Bioactivities of Secondary Metabolites Derived from Endophytic Fungi Isolated from Ethnomedicinal Plants of Tujia in Hubei Province: A Review[J]. Natural Products and Bioprospecting, 2021, 11(2): 185-205.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00295-5 OR http://npb.kib.ac.cn/EN/Y2021/V11/I2/185

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