| ORIGINAL ARTICLES |
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Furostanol Saponins from Asparagus cochinchinensis and Their Cytotoxicity |
| Ruo-Song Zhang1,2, Yang-Yang Liu3, Pei-Feng Zhu1,2, Qiong Jin1,2, Zhi Dai3, Xiao-Dong Luo1,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, China |
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Abstract Phytochemical investigation on the roots of Asparagus cochinchinensis led to the isolation of one new furostanol saponin, named 26-O-β-D-glucopyranosyl-22α-hydroxyl-(25R)-Δ5(6)-furost-3β,26-diol-3-O-α-L-rhamnopyranosyl-(1→ 2)-[β-Dglucopyranosyl-(1→ 4)-α-L-rhamnopyranosyl-(1→ 4)]-β-D-glucopyranoside (1), along with three known congeners (2-4). The structure of new saponin was elucidated via comprehensive inspection of its HRMS and NMR spectral data as well as chemical technology, whereas those of known ones were identified by comparison of their NMR and MS spectral data with those reported in literatures. All isolated saponins were evaluated for their cytotoxic effects on two human liver (MHCC97H) and lung adenocarcinoma (H1299) cancer cells in vitro. Among them, both 1 and 2 showed significant cytotoxicity against above mentioned cell lines. Further studies revealed that these two saponins could significantly inhibit their proliferation of MHCC97H and H1299 cells.
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| Keywords
Steroid saponins
Asparagus cochinchinensis
Cytotoxicity
Structural elucidation
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| Fund:This study was financially supported by the National Natural Science Foundation of China (Grant Nos. 31770388 and U1802281) and the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (Grant No. 2019QZKK0502). |
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Corresponding Authors:
Xiao-Dong Luo
E-mail: xdluo@mail.kib.ac.cn
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Issue Date: 10 December 2021
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