Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus <i>Irpex lacteus</i>

doi:10.1007/s13659-018-0160-3

Natural Products and Bioprospecting

2018, Vol. 8

Issue (3) : 171-176 DOI: 10.1007/s13659-018-0160-3

ORIGINAL ARTICLE

Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus

Yang Tang^1,2,3, Zhen-Zhu Zhao², Zheng-Hui Li², Tao Feng², He-Ping Chen², Ji-Kai Liu²

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Abstract
References
Related Articles
Metrics

Download: PDF(3794 KB) HTML ()
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A-D (1-4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS spectroscopic analysis. Irpexoate B (2) displayed weak cytotoxicity against four human cancer cell lines (A-549, SMMC-7721, MCF-7, SW480) with IC₅₀ values varying from 22.9 to 34.0 μM, and irpexoate D (4) showed weak cytotoxicity against the human cancer cell line SW480 with an IC₅₀ value of 35.2 μM.

Keywords Irpex lacteus Meruliaceae Eburicane Malonyl Cytotoxicity

Fund:This work was financially supported by National Natural Science Foundation of China (81561148013), the Key Projects of Technological Innovation of Hubei Province (2016ACA138), and the Fundamental Research Funds for the Central University, South-Central University for Nationalities (CZT18014, CZT18013).

Corresponding Authors: He-Ping Chen, Ji-Kai Liu E-mail: chenhp@mail.scuec.edu.cn;jkliu@mail.kib.ac.cn

Issue Date: 02 June 2018

	Service

	E-mail this article
	E-mail Alert
	RSS
	Articles by authors

	Yang Tang
	Zhen-Zhu Zhao
	Zheng-Hui Li
	Tao Feng
	He-Ping Chen
	Ji-Kai Liu

Trendmd:

Cite this article:

Yang Tang,Zhen-Zhu Zhao,Zheng-Hui Li, et al. Irpexoates A-D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus[J]. Natural Products and Bioprospecting, 2018, 8(3): 171-176.

URL:

http://npb.kib.ac.cn/EN/10.1007/s13659-018-0160-3 OR http://npb.kib.ac.cn/EN/Y2018/V8/I3/171

1. H.P. Chen, J.K. Liu, Prog. Chem. Org. Nat. Prod. 106, 1-201 (2017)
2. X.M. Dong, X.H. Song, K.B. Liu, C.H. Dong, Mycosystema 36, 28-34 (2017)
3. J.H. Ding, Z.H. Li, T. Feng, J.K. Liu, Fitoterapia 125, 245-248 (2018)
4. J.H. Ding, T. Feng, B.K. Cui, K. Wei, Z.H. Li, J.K. Liu, Tetrahedron Lett. 54, 2651-2654 (2013)
5. D. Saggerson, Annu. Rev. Nutr. 28, 253-272 (2008)
6. H.P. Chen, Z.Z. Zhao, Z.H. Li, Z.J. Dong, K. Wei, X. Bai, L. Zhang, C.N. Wen, T. Feng, J.K. Liu, Chem. Open 5, 142-149 (2016)

[1]	He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, Ji-Kai Liu. *Seco-tremulane Sesquiterpenoids from the Cultures of the Medicinal Fungus Irpex lacteus* HFG1102**[J]. Natural Products and Bioprospecting, 2018, 8(2): 113-119.
[2]	Rong Chen, Jian-Wei Tang, Xing-Ren Li, Miao Liu, Wen-Ping Ding, Yuan-Fei Zhou, Wei-Guang Wang, Xue Du, Han-Dong Sun, Pema-Tenzin Puno. *Secondary Metabolites from the Endophytic Fungus Xylaria* sp. Hg1009**[J]. Natural Products and Bioprospecting, 2018, 8(2): 121-129.
[3]	Manar Adam, Gihan O. M. Elhassan, Sakina Yagi, Fatma Sezer Senol, Ilkay Erdogan Orhan, Abdel Azim Ahmed, Thomas Efferth. In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan[J]. Natural Products and Bioprospecting, 2018, 8(2): 97-105.
[4]	Zhen-Xiong Wang, Shen Qin, Li-Hua Xu, He-Ping Chen, Huan Sun, Rong Huang, Zheng-Hui Li, Tao Feng, Ji-Kai Liu. *Xylanilyticolides A-C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica* YIM 61515**[J]. Natural Products and Bioprospecting, 2018, 8(2): 91-95.
[5]	Xing Yu, Kai-Ting Duan, Zhen-Xiong Wang, He-Ping Chen, Xiao-Qing Gan, Rong Huang, Zheng-Hui Li, Tao Feng, Ji-Kai Liu. Anemhupehins A-C, Podocarpane Diterpenoids from Anemone hupehensis[J]. Natural Products and Bioprospecting, 2018, 8(1): 31-35.
[6]	Xu-Jie Qin, Tong Shu, Qian Yu, Huan Yan, Wei Ni, Lin-Kun An, Pan-Pan Li, Yin-E Zhi, Afsar Khan, Hai-Yang Liu. Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus[J]. Natural Products and Bioprospecting, 2017, 7(4): 315-321.
[7]	Xin Wei, Afsar Khan, Da Song, Zhi Dai, Ya-Ping Liu, Hao-Fei Yu, Bei Wang, Pei-Feng Zhu, Cai-Feng Ding, Xu-Dong Zhao, Yi-Fen Wang, Xiao-Dong Luo. *Three New Pyridine Alkaloids from Vinca major* Cultivated in Pakistan**[J]. Natural Products and Bioprospecting, 2017, 7(4): 323-327.
[8]	Miao Liu, Zheng-Xi Hu, Yuan-Qing Luo, Min Zhou, Wei-Guang Wang, Xiao-Nian Li, Xue Du, Jian-Xin Pu, Han-Dong Sun. Two New Compounds from Schisandra propinqua var. propinqua[J]. Natural Products and Bioprospecting, 2017, 7(3): 257-262.
[9]	Li-Xia Wang, Hai-Rong Zheng, Fu-Cai Ren, Tian-Ge Chen, Xiang-Mei Li, Xian-Jun Jiang, Fei Wang. Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis[J]. Natural Products and Bioprospecting, 2017, 7(2): 201-206.
[10]	Satheesh Kumar Palanisamy, N. M. Rajendran, Angela Marino. Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development[J]. Natural Products and Bioprospecting, 2017, 7(1): 1-111.
[11]	Mehtab Parveen, Faheem Ahmad, Ali Mohammed Malla, Shaista Azaz, Mahboob Alam, Omer A. Basudan, Manuela Ramos Silva, Pedro S. Pereira Silva. *Acetylcholinesterase and Cytotoxic Activity of Chemical Constituents of Clutia lanceolata* Leaves and its Molecular Docking Study**[J]. Natural Products and Bioprospecting, 2016, 6(6): 267-278.
[12]	Qian-Qian Meng, Xing-Rong Peng, Shuang-Yang Lu, Luo-Sheng Wan, Xia Wang, Jin-Run Dong, Rui Chu, Lin Zhou, Xiao-Nian Li, Ming-Hua Qiu. Lactam Triterpenoids from the Bark of Toona sinensis[J]. Natural Products and Bioprospecting, 2016, 6(5): 239-245.
[13]	Xiang-Mei Li, Xian-Jun Jiang, Ku Yang, Li-Xia Wang, Shi-Zhen Wen, Fei Wang. Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata[J]. Natural Products and Bioprospecting, 2016, 6(5): 233-237.
[14]	Vincent E. Rasamison, Peggy J. Brodie, Emilio F. Merino, Maria B. Cassera, Michel A. Ratsimbason, Stephan Rakotonandrasana, Andriamalala Rakotondrafara, Elie Rafidinarivo, David G. I. Kingston, Harinantenaina L. Rakotondraibe. *Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis* (Baker) T. G. Hartley**[J]. Natural Products and Bioprospecting, 2016, 6(5): 261-265.
[15]	Ling Ni, Xiu-Hong Zhong, Jie Cai, Mei-Fen Bao, Bing-Jie Zhang, Jing Wu, Xiang-Hai Cai. Five New Alkaloids from Cephalotaxus lanceolata and C. fortunei var. alpina[J]. Natural Products and Bioprospecting, 2016, 6(3): 149-154.

Viewed

Full text

Abstract

Cited

Shared

Discussed