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Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis |
| Conrad V. Simoben1, Fidele Ntie-Kang1,2, Sergi H. Akone3,4, Wolfgang Sippl1 |
1 Institute of Pharmacy, Martin-Luther University of HalleWittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle(Saale), Germany;
2 Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63, Buea 00237, Cameroon;
3 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse1, Geb. 26. 23, Duesseldorf 40225, Germany;
4 Department of Chemistry, Faculty of Science, University of Douala, PO Box 24157, Douala 00237, Cameroon |
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Abstract Parasitic diseases continue to represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases. In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species. In each subparagraph, emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds. Suggestions for future drug development from African medicinal plants have also been provided. This review covering 167 references, including 82 compounds, provides information published within two decades (1997-2017).
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African medicinal plants
Leishmaniasis
Natural products
Parasitic diseases
Schistosomiasis Trypanosomiasis
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Corresponding Authors:
Fidele Ntie-Kang
E-mail: ntiekfidele@gmail.com
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Issue Date: 02 June 2018
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