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Current Perspective in the Discovery of Anti-aging Agents from Natural Products |
| Ai-Jun Ding1,2, Shan-Qing Zheng1,2, Xiao-Bing Huang1,2, Ti-Kun Xing1,2, Gui-Sheng Wu1,3, Hua-Ying Sun1, Shu-Hua Qi4, Huai-Rong Luo1,3,5 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
2. University of Chinese Academy of Sciences, Beijing 100039, China;
3. Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China;
4. Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, Guangdong, China;
5. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, 134 Lanhei Road, Kunming 650201, Yunnan, China |
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Abstract Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing antiaging medicine from natural products.
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| Keywords
Aging
Natural products
Anti-aging
Drug screening
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| Fund:This work was supported by the Natural Science Foundation of China (81671405 and 81370453), Natural Science Foundation of Yunnan province (2013FA045 and 2015FB172), and Open Funds of Guangdong Key Laboratory of Marine Materia Medica. |
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Issue Date: 06 February 2018
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