| ORIGINAL ARTICLES |
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Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum |
| Chen Shi1, Yue-Ling Peng2, Juan He1, Zheng-Hui Li1, Ji-Kai Liu1, Tao Feng1 |
1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 The Third People's Hospital of Datong, Datong 037000, People's Republic of China |
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Abstract Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC50 values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.
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| Keywords
Tricholoma pardinum
Tricholoma triterpenoids
Chemical conversion
Cytotoxicity
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| Fund:This work was financially supported by the National Natural Science Foundation of China (81872762) and the Hubei Provincial Natural Science Foundation of China (2019CFB387). The authors thank the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central University for Nationalities for spectra test. |
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Corresponding Authors:
Tao Feng
E-mail: tfeng@mail.scuec.edu.cn
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Issue Date: 07 April 2021
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