| ORIGINAL ARTICLES |
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Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata |
| Chang-An Geng1, Zhen-Tao Deng1, Qian Huang1, Chun-Lei Xiang2, Ji-Jun Chen1,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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Abstract Ten 3,5-dimethylcoumarins (1-6 and 8-11) involving six new ones (1-6), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and C. pseudobracteata. The structures of the new compounds were determined by extensive HRESIMS, 1D and 2D NMR spectroscopic analyses. According to the substitution at C-5, these coumarins were classified into 5-methyl, 5-hydroxymethyl, 5-formyl, and 5-nor types. All the isolates were assayed for their inhibition on α-glucosidase, protein tyrosine phosphatase 1B, and T-cell protein tyrosine phosphatase in vitro.
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| Keywords
3,5-Dimethylcoumarins
3-Methylcoumarin
Chelonopsis
Enzyme inhibition
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| Fund:This work was supported by the Yunnan Wanren Project (YNWR-QNBJ-2018-061), the Natural Science Foundation of Yunnan Province (2019FI017), and the Reserve Talents of Young and Middle-Aged Academic and Technical Leaders in Yunnan Province. |
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Corresponding Authors:
Ji-Jun Chen
E-mail: chenjj@mail.kib.ac.cn
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Issue Date: 10 December 2021
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