| REVIEWS |
|
|
|
|
|
Eco-friendly approaches to phytochemical production: elicitation and beyond |
| Kritika Jalota1, Vikas Sharma1, Chiti Agarwal2, Suruchi Jindal1 |
1. Division of Molecular Biology and Genetic Engineering, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, 144411, India;
2. Washington State University, Pullman, USA |
|
|
|
|
Abstract Highly ameliorated phytochemicals from plants are recognized to have numerous beneficial effects on human health. However, obtaining secondary metabolites directly from wild plants is posing a great threat to endangered plant species due to their over exploitation. Moreover, due to complicated structure and stereospecificity chemical synthesis of these compounds is a troublesome procedure. As a result, sustainable and ecofriendly in vitro strategy has been adopted for phytochemicals production. But, lack of fully differentiated cells lowers down cultured cells productivity. Consequently, for enhancing yield of metabolites produced by cultured plant cells a variety of methodologies has been followed one such approach includes elicitation of culture medium that provoke stress responses in plants enhancing synthesis and storage of bioactive compounds. Nevertheless, for conclusive breakthrough in synthesizing bioactive compounds at commercial level in-depth knowledge regarding metabolic responses to elicitation in plant cell cultures is needed. However, technological advancement has led to development of molecular based approaches like metabolic engineering and synthetic biology which can serve as promising path for phytochemicals synthesis. This review article deals with classification, stimulating effect of elicitors on cultured cells, parameters of elicitors and action mechanism in plants, modern approaches like metabolic engineering for future advances.
|
| Keywords
In-vitro system
Abiotic/biotic elicitors
Plant secondary metabolites
Metabolic engineering
CRISPR-Cas
|
| Fund:No funding has been obtained for this work. |
|
Corresponding Authors:
Suruchi Jindal,E-mail:suruchi.28640@lpu.co.in
E-mail: suruchi.28640@lpu.co.in
|
|
Issue Date: 19 February 2024
|
|
|
[1] Bhaskar R, Xavier LS, Udayakumaran G, Kumar DS, Venkatesh R, Nagella P. Biotic elicitors: a boon for the in-vitro production of plant secondary metabolites. Plant Cell Tissue and Organ Culture (PCTOC). 2022;149(1–2):7–24.
[2] Singh A, Dwivedi P. Methyl-jasmonate and salicylic acid as potent elicitors for secondary metabolite production in medicinal plants: a review. J Pharmacogn Phytochem. 2018;7(1):750–7.
[3] Divekar PA, Narayana S, Divekar BA, Kumar R, Gadratagi BG, Ray A, Singh AK, Rani V, Singh V, Singh AK, Kumar A. Plant secondary metabolites as defense tools against herbivores for sustainable crop protection. Int J Mol Sci. 2022;23(5):2690.
[4] Naik PM, Al-Khayri JM. Abiotic and biotic elicitors-role in secondary metabolites production through in vitro culture of medicinal plants. Abiotic and biotic stress in plants—recent advances and future perspectives. Rijeka: In Tech. 2016:247–277.
[5] Ramirez-Estrada K, Vidal-Limon H, Hidalgo D, Moyano E, Golenioswki M, Cusidó RM, Palazon J. Elicitation, an effective strategy for the biotechnological production of bioactive high-added value compounds in plant cell factories. Molecules. 2016;21(2):182.
[6] Huang P, Xia L, Zhou L, Liu W, Wang P, Qing Z, Zeng J. Influence of different elicitors on BIA production in Macleaya cordata. Sci Rep. 2021;11(1):619.
[7] Manorma S, Archana S, Ashwani K, Basu SK. Enhancement of secondary metabolites in cultured plant cells through stress stimulus. Am J Plant Physiol. 2011;6(2):50–71.
[8] Gadzovska Simic S, Tusevski O, Maury S, Delaunay A, Joseph C, Hagège D. Effects of polysaccharide elicitors on secondary metabolite production and antioxidant response in Hypericum perforatum L. shoot cultures. Sci World J. 2014;2014:609649.
[9] Marchev AS, Yordanova ZP, Georgiev MI. Green (cell) factories for advanced production of plant secondary metabolites. Crit Rev Biotechnol. 2020;40(4):443–58.
[10] Patel H, Krishnamurthy R. Elicitors in plant tissue culture. J Pharmacogn Phytochem. 2013;2(2):60–5.
[11] Gupta R, Jain D. Transforming plant secondary metabolite production through the application of PTC and elicitor technology. J Adv Sci Res. 2022;13(01):75–86.
[12] Naik PM, Al-Khayri JM. Impact of abiotic elicitors on in vitro production of plant secondary metabolites: a review. J Adv Res Biotechnol. 2016;1(2):1–7.
[13] Qaderi MM, Martel AB, Strugnell CA. Environmental factors regulate plant secondary metabolites. Plants. 2023;12(3):447.
[14] Baenas N, García-Viguera C, Moreno DA. Elicitation: a tool for enriching the bioactive composition of foods. Molecules. 2014;19(9):13541–63.
[15] Aguirre-Becerra H, Vazquez-Hernandez MC, de la Saenz OD, Alvarado-Mariana A, Guevara-Gonzalez RG, Garcia-Trejo JF, Feregrino-Perez AA. Role of stress and defense in plant secondary metabolites production. Bioactive natural products for pharmaceutical applications. 2021:151–195.
[16] Sutini W, Augustien N, Purwanto DA, Muslihatin W. The production of cinnamic acid secondary metabolites through in vitro culture of callus Camellia sinensis L with the elicitor of cobalt metal ions. In Proceedings of the International Conference on Biology and Applied Science, Malang, Indonesia, 20 March 2019; American Institute of Physics Inc.: Malang, Indonesia, 2019; Volume 2120, pp. 030028-1-030028-5.
[17] Gorelick J, Bernstein N. Elicitation: an underutilized tool in the development of medicinal plants as a source of therapeutic secondary metabolites. Adv Agron. 2014;124:201–30.
[18] Ali B. Salicylic acid: an efficient elicitor of secondary metabolite production in plants. Biocatal Agric Biotechnol. 2021;31:101884.
[19] Alcalde MA, Perez-Matas E, Escrich A, Cusido RM, Palazon J, Bonfill M. Biotic elicitors in adventitious and hairy root cultures: a review from 2010 to 2022. Molecules. 2022;27(16):5253.
[20] Doernenburg H, Knorr D. Effectiveness of plant-derived and microbial polysaccharides as elicitors for anthraquinone synthesis in Morinda citrifolia cultures. J Agric Food Chem. 1994;42(4):1048–52.
[21] Namdeo AG. Plant cell elicitation for production of secondary metabolites: a review. Pharmacogn Rev. 2007;1(1):69–79.
[22] Halder M, Sarkar S, Jha S. Elicitation: a biotechnological tool for enhanced production of secondary metabolites in hairy root cultures. Eng Life Sci. 2019;19(12):880–95.
[23] Jeong GT, Park DH. Enhanced secondary metabolite biosynthesis by elicitation in transformed plant root system: effect of abiotic elicitors. Appl Biochem Biotechnol. 2006;130:436–46.
[24] Chodisetti B, Rao K, Gandi S, Giri A. Gymnemic acid enhancement in the suspension cultures of Gymnema sylvestre by using the signaling molecules—methyl jasmonate and salicylic acid. Vitro Cell Dev Biology-Plant. 2015;51:88–92.
[25] Cai Z, Kastell A, Speiser C, Smetanska I. Enhanced resveratrol production in Vitis vinifera cell suspension cultures by heavy metals without loss of cell viability. Appl Biochem Biotechnol. 2013;171:330–40.
[26] DiCosmo F, Misawa M. Plant cell and tissue culture: alternatives for metabolite production. Biotechnol Adv. 1995;13(3):425–53.
[27] Srivastava M, Sharma S, Misra P. Elicitation based enhancement of secondary metabolites in Rauwolfia serpentina and Solanum khasianum hairy root cultures. Pharmacogn Mag. 2016;12(Suppl 3):315.
[28] Mohaddab M, El Goumi Y, Gallo M, Montesano D, Zengin G, Bouyahya A, Fakiri M. Biotechnology and in vitro culture as an alternative system for secondary metabolite production. Molecules. 2022;27(22):8093.
[29] Bakhtiari MA, Golkar P. The effects of callus elicitation on lepidine, phenolic content, and antioxidant activity of Lepidium sativum L.: Chitosan and gibberellic acid. J Plant Growth Regul. 2022;41(3):1148–60.
[30] Farhadi S, Moieni A, Safaie N, Sabet MS, Salehi M. Fungal cell wall and methyl-β–cyclodextrin synergistically enhance paclitaxel biosynthesis and secretion in Corylus avellana cell suspension culture. Sci Rep. 2020;10(1):5427.
[31] Torkamani MR, Jafari M, Abbaspour N, Heidary R, Safaie N. Enhanced production of valerenic acid in hairy root culture of Valeriana officinalis by elicitation. Cent Eur J Biol. 2014;9:853–63.
[32] Xu XD, Liang WX, Yao L, Paek KY, Wang J, Gao WY. Production of ginsenoside by Chaetomium sp. and its effect on enhancing the contents of ginsenosides in Panax ginseng adventitious roots. Biochem Eng J. 2021;174:108100.
[33] Taghizadeh M, Nekonan MS, Setorki M. Enhancement production of phenolic compounds in the cell suspension culture of Iberis amara L.: the effect of chitosan elicitation. Res Sq. 2021.
[34] Osman NI, Jaafar Sidik N, Awal A. Efficient enhancement of gallic acid accumulation in cell suspension cultures of Barringtonia racemosa L. by elicitation. Plant Cell Tissue Organ Cult. 2018;135:203–12.
[35] Sharma M, Ahuja A, Gupta R, Mallubhotla S. Enhanced bacoside production in shoot cultures of Bacopa monnieri under the influence of abiotic elicitors. Nat Prod Res. 2015;29(8):745–9.
[36] Baldi A, Dixit VK. Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. Bioresour Technol. 2008;99(11):4609–14.
[37] Kitisripanya T, Komaikul J, Tawinkan N, Atsawinkowit C, Putalun W. Dicentrine production in callus and cell suspension cultures of Stephania venosa. Nat Prod Commun. 2013;8(4):443–5.
[38] Yukimune Y, Tabata H, Higashi Y, Hara Y. Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nat Biotechnol. 1996;14(9):1129–32.
[39] Roat C, Ramawat KG. Elicitor-induced accumulation of stilbenes in cell suspension cultures of Cayratia trifolia (L.) Domin. Plant Biotechnol Rep. 2009;3:135–8.
[40] Wu JY, Ng J, Shi M, Wu SJ. Enhanced secondary metabolite (tanshinone) production of Salvia miltiorrhiza hairy roots in a novel root–bacteria coculture process. Appl Microbiol Biotechnol. 2007;77:543–50.
[41] Açıkgöz MA. Establishment of cell suspension cultures of Ocimum basilicum L. and enhanced production of pharmaceutical active ingredients. Ind Crops Prod. 2020;148:112278.
[42] Alsoufi AS, Pączkowski C, Szakiel A, Długosz M. Effect of jasmonic acid and chitosan on triterpenoid production in Calendula officinalis hairy root cultures. Phytochem Lett. 2019;31:5–11.
[43] Wawrosch C, Zotchev SB. Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook. Appl Microbiol Biotechnol. 2021;105(18):6649–68.
[44] Kumar P, Chaturvedi R, Sundar D, Bisaria VS. Piriformospora indica enhances the production of pentacyclic triterpenoids in Lantana camara L. suspension cultures. Plant Cell Tissue Organ Culture (PCTOC). 2016;125:23–9.
[45] Narayani M, Srivastava S. Elicitation: a stimulation of stress in in vitro plant cell/tissue cultures for enhancement of secondary metabolite production. Phytochem Rev. 2017;16:1227–52.
[46] Chodisetti B, Rao K, Gandi S, Giri A. Improved gymnemic acid production in the suspension cultures of Gymnema sylvestre through biotic elicitation. Plant Biotechnol Rep. 2013;7:519–25.
[47] Sharma P, Yadav S, Srivastava A, Shrivastava N. Methyl jasmonate mediates upregulation of bacoside A production in shoot cultures of Bacopa monnieri. Biotechnol Lett. 2013;35:1121–5.
[48] Shakeran Z, Keyhanfar M, Asghari G, Ghanadian M. Improvement of atropine production by different biotic and abiotic elicitors in hairy root cultures of Datura metel. Turkish J Biol. 2015;39(1):111–8.
[49] Namdeo A, Patil S, Fulzele DP. Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus. Biotechnol Prog. 2002;18(1):159–62.
[50] Sharma SN, Jha Z, Sinha RK, Geda AK. Jasmonate-induced biosynthesis of andrographolide in Andrographis paniculata. Physiol Plant. 2015;153(2):221–9.
[51] Sivanandhan G, Kapil Dev G, Jeyaraj M, Rajesh M, Arjunan A, Muthuselvam M, Manickavasagam M, Selvaraj N, Ganapathi A. Increased production of withanolide A, withanone, and withaferin A in hairy root cultures of Withania somnifera (L.) Dunal elicited with methyl jasmonate and salicylic acid. Plant Cell Tissue and Organ Culture (PCTOC). 2013;114:121–9.
[52] Sumit G, Amit M, Archana T. Catharanthus alkaloids and their enhanced production using elicitors: a review. Int J Pharm Technol. 2011;3(1):713–24.
[53] Docimo T, Davis AJ, Luck K, Fellenberg C, Reichelt M, Phillips M, Gershenzon J, D’Auria JC. Influence of medium and elicitors on the production of cocaine, amino acids and phytohormones by Erythroxylum coca calli. Plant Cell, Tissue Organ Culture. 2015;120:1061–75.
[54] Scheible WR, Morcuende R, Czechowski T, Fritz C, Osuna D, Palacios-Rojas N, Schindelasch D, Thimm O, Udvardi MK, Stitt M. Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen. Plant Physiol. 2004;136(1):2483–99.
[55] Kováčik J, Klejdus B, Babula P, Jarošová M. Variation of antioxidants and secondary metabolites in nitrogen-deficient barley plants. J Plant Physiol. 2014;171(3–4):260–8.
[56] Fritz C, Palacios-Rojas N, Feil R, Stitt M. Regulation of secondary metabolism by the carbon–nitrogen status in tobacco: nitrate inhibits large sectors of phenylpropanoid metabolism. Plant J. 2006;46(4):533–48.
[57] Bensaddek L, Gillet F, Saucedo JE, Fliniaux MA. The effect of nitrate and ammonium concentrations on growth and alkaloid accumulation of Atropa belladonna hairy roots. J Biotechnol. 2001;85(1):35–40.
[58] Thakur M, Sohal BS. Role of elicitors in inducing resistance in plants against pathogen infection: a review. ISRN Biochem. 2013;2013:762412. https://doi.org/10.1155/2013/762412.
[59] Park WT, Arasu MV, Al-Dhabi NA, Yeo SK, Jeon J, Park JS, Lee SY, Park SU. Yeast extract and silver nitrate induce the expression of phenylpropanoid biosynthetic genes and induce the accumulation of rosmarinic acid in Agastache rugosa cell culture. Molecules. 2016;21(4):426.
[60] Bonfill M, Mangas S, Moyano E, Cusido RM, Palazón J. Production of centellosides and phytosterols in cell suspension cultures of Centella asiatica. Plant Cell Tissue and Organ Culture (PCTOC). 2011;104:61–7.
[61] Birchfield AS, McIntosh CA. Metabolic engineering and synthetic biology of plant natural products–a mini review. Curr Plant Biol. 2020;24:100163.
[62] Nielsen E, Temporiti ME, Cella R. Improvement of phytochemical production by plant cells and organ culture and by genetic engineering. Plant Cell Rep. 2019;38(10):1199–215.
[63] Sharma SA, Sharma SH, Kukreja SA, Jadon VS, Sharma VI. Plant tissue culture methods in secondary metabolite production-A mini review. Plant Cell Biotechnol Mol Biol. 2020;21:144–53.
[64] Isah T, Umar S, Mujib A, Sharma MP, Rajasekharan PE, Zafar N, Frukh A. Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield. Plant Cell Tissue and Organ Culture (PCTOC). 2018;132:239–65.
[65] Dey A. CRISPR/Cas genome editing to optimize pharmacologically active plant natural products. Pharmacol Res. 2021;164:105359.
[66] Lakshmaiah VV, Banadka A, Thirumoorthy G, Naik PM, Al-Khayri JM, Nagella P. In Vitro Production of Bioactive compounds from Plant Cell Culture. In Nutraceuticals Production from Plant Cell Factory 2022 pp. 29–67). Singapore: Springer Nature Singapore.
[67] Arya SS, Kumari DD, Rookes JE, Cahill DM, Lenka SK. Rice cell suspension culture as a model for producing high-value recombinant proteins and plant specialized metabolites. Plant Cell Tissue Organ Culture. 2021;145:463–86.
[68] Cusido RM, Onrubia M, Sabater-Jara AB, Moyano E, Bonfill M, Goossens A, Pedreño MA, Palazon J. A rational approach to improving the biotechnological production of taxanes in plant cell cultures of Taxus spp. Biotechnol Adv. 2014;32(6):1157–67.
[69] Yao D, Zhang Z, Chen Y, Lin Y, Xu X, Lai Z. Transcriptome analysis reveals differentially expressed genes that regulate biosynthesis of the active compounds with methyl jasmonate in rosemary suspension cells. Genes. 2021;13(1):67.
[70] Cravens A, Payne J, Smolke CD. Synthetic biology strategies for microbial biosynthesis of plant natural products. Nat Commun. 2019;10(1):2142.
[71] Zhu X, Liu X, Liu T, Wang Y, Ahmed N, Li Z, Jiang H. Synthetic biology of plant natural products: from pathway elucidation to engineered biosynthesis in plant cells. Plant Commun. 2021;2(5):100229.
[72] Niazian M. Application of genetics and biotechnology for improving medicinal plants. Planta. 2019;249:953–73.
[73] Sabzehzari M, Zeinali M, Naghavi MR. CRISPR-based metabolic editing: next-generation metabolic engineering in plants. Gene. 2020;759:144993.
[74] Mipeshwaree Devi A, Khedashwori Devi K, Premi Devi P, Lakshmipriyari Devi M, Das S. Metabolic engineering of plant secondary metabolites: prospects and its technological challenges. Front Plant Sci. 2023;14:1171154.
[75] Loyola-Vargas VM, Ochoa-Alejo N. An introduction to plant tissue culture: advances and perspectives. Methods Mol Biol. 2018;1815:3–13.
[76] Kowalczyk T, Merecz-Sadowska A, Picot L, Brčić Karačonji I, Wieczfinska J, Śliwiński T, Sitarek P. Genetic manipulation and bioreactor culture of plants as a tool for industry and its applications. Molecules. 2022;27(3):795.
[77] Wu T, Kerbler SM, Fernie AR, Zhang Y. Plant cell cultures as heterologous bio-factories for secondary metabolite production. Plant Commun. 2021;2(5):100235. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
